Gene description for CCDC69
Gene name coiled-coil domain containing 69
Gene symbol CCDC69
Other names/aliases -
Species Homo sapiens
 Database cross references - CCDC69
ExoCarta ExoCarta_26112
Vesiclepedia VP_26112
Entrez Gene 26112
HGNC 24487
UniProt A6NI79  
 CCDC69 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for CCDC69
Molecular Function
    microtubule binding GO:0008017 IBA
Biological Process
    spindle midzone assembly GO:0051255 IMP
Subcellular Localization
    nucleus GO:0005634 IBA
    cytoplasm GO:0005737 IBA
    midbody GO:0030496 IEA
    spindle midzone GO:0051233 IDA
 Experiment description of studies that identified CCDC69 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for CCDC69
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ASH2L 9070
Affinity Capture-MS Homo sapiens
2 RMI2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 PMPCB 9512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 GRN 2896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 PSMA3 5684
Two-hybrid Homo sapiens
6 ZAK 51776
Two-hybrid Homo sapiens
7 MTA2 9219
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 MYH8 4626
Affinity Capture-MS Homo sapiens
9 GGPS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PSME3 10197
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 FAM192A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 LONP1 9361
Affinity Capture-MS Homo sapiens
13 MYL1 4632
Affinity Capture-MS Homo sapiens
14 RMI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SMURF1 57154
Biochemical Activity Homo sapiens
16 PSMG4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 TOP3A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 PM20D2 135293
Affinity Capture-MS Homo sapiens
19 CLTCL1 8218
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 MAP3K1 4214
Biochemical Activity Homo sapiens
21 ACTA1 58
Affinity Capture-MS Homo sapiens
22 PSMG3 84262
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 EPDR1 54749
Affinity Capture-MS Homo sapiens
24 NUDT8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PMPCA 23203
Affinity Capture-MS Homo sapiens
26 MYH7 4625
Affinity Capture-MS Homo sapiens
27 MMADHC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 MYH2  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CCDC69 is involved
No pathways found





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