Gene description for KIF3C
Gene name kinesin family member 3C
Gene symbol KIF3C
Other names/aliases -
Species Homo sapiens
 Database cross references - KIF3C
ExoCarta ExoCarta_3797
Vesiclepedia VP_3797
Entrez Gene 3797
HGNC 6321
MIM 602845
UniProt O14782  
 KIF3C identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for KIF3C
Molecular Function
    cytoskeletal motor activity GO:0003774 TAS
    microtubule motor activity GO:0003777 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    microtubule binding GO:0008017 IBA
    ATP hydrolysis activity GO:0016887 IBA
Biological Process
    microtubule-based movement GO:0007018 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    kinesin complex GO:0005871 IBA
    microtubule GO:0005874 IBA
    cilium GO:0005929 TAS
    ciliary tip GO:0097542 TAS
 Experiment description of studies that identified KIF3C in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for KIF3C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KIF3B 9371
Affinity Capture-MS Homo sapiens
2 DYRK2 8445
Affinity Capture-MS Homo sapiens
3 DISC1 27185
Two-hybrid Homo sapiens
4 CDC5L 988
Two-hybrid Homo sapiens
5 SNX27 81609
Affinity Capture-MS Homo sapiens
6 STK4 6789
Affinity Capture-MS Homo sapiens
7 KIF1BP 26128
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 KIF3A 11127
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ZC3H3  
Affinity Capture-MS Homo sapiens
10 SAV1  
Affinity Capture-MS Homo sapiens
11 KIFAP3 22920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 AKAP12 9590
Affinity Capture-MS Homo sapiens
13 NCKAP5  
Affinity Capture-MS Homo sapiens
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