Gene description for MAD2L2
Gene name MAD2 mitotic arrest deficient-like 2 (yeast)
Gene symbol MAD2L2
Other names/aliases MAD2B
Species Homo sapiens
 Database cross references - MAD2L2
ExoCarta ExoCarta_10459
Entrez Gene 10459
HGNC 6764
MIM 604094
UniProt Q9UI95  
 MAD2L2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for MAD2L2
Molecular Function
    JUN kinase binding GO:0008432 IDA
    protein binding GO:0005515 IPI
    RNA polymerase II activating transcription factor binding GO:0001102 IPI
Biological Process
    regulation of cell growth GO:0001558 IGI
    negative regulation of APC-Cdc20 complex activity GO:0060564 IDA
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA
    negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IMP
    negative regulation of transcription regulatory region DNA binding GO:2000678 IMP
    translesion synthesis GO:0019985 TAS
    double-strand break repair GO:0006302 IGI
    error-prone translesion synthesis GO:0042276 TAS
    cell division GO:0051301 IEA
    negative regulation of epithelial to mesenchymal transition GO:0010719 IMP
    transcription, DNA-templated GO:0006351 IEA
    DNA repair GO:0006281 TAS
    DNA damage response, signal transduction resulting in transcription GO:0042772 IDA
    negative regulation of protein catabolic process GO:0042177 IDA
    negative regulation of transcription by competitive promoter binding GO:0010944 IMP
    actin filament organization GO:0007015 IMP
    mitotic nuclear division GO:0007067 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IMP
    mitotic spindle assembly checkpoint GO:0007094 TAS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleoplasm GO:0005654 TAS
    zeta DNA polymerase complex GO:0016035 IDA
    spindle GO:0005819 IDA
    nucleus GO:0005634 IDA
    anaphase-promoting complex GO:0005680 IDA
 Experiment description of studies that identified MAD2L2 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for MAD2L2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CDC20  
Reconstituted Complex Homo sapiens
2 ADAM15 8751
Two-hybrid Homo sapiens
3 MAD2L2 10459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PRRC2A 7916
Two-hybrid Homo sapiens
5 CDH1 999
Reconstituted Complex Homo sapiens
6 ADAM9 8754
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
7 REV3L  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MAD2L2 is involved
Translesion synthesis by POLI TAS Reactome
Translesion synthesis by POLK TAS Reactome
Translesion synthesis by REV1 TAS Reactome

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