Gene description for SULT1A1
Gene name sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
Gene symbol SULT1A1
Other names/aliases HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
Species Homo sapiens
 Database cross references - SULT1A1
ExoCarta ExoCarta_6817
Vesiclepedia VP_6817
Entrez Gene 6817
HGNC 11453
MIM 171150
UniProt P50225  
 SULT1A1 identified in sEVs derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for SULT1A1
Molecular Function
    aryl sulfotransferase activity GO:0004062 IBA
    aryl sulfotransferase activity GO:0004062 IDA
    protein binding GO:0005515 IPI
    sulfotransferase activity GO:0008146 IDA
    flavonol 3-sulfotransferase activity GO:0047894 IDA
    steroid sulfotransferase activity GO:0050294 IDA
    3'-phosphoadenosine 5'-phosphosulfate binding GO:0050656 IDA
Biological Process
    ethanol catabolic process GO:0006068 IDA
    catecholamine metabolic process GO:0006584 IEA
    xenobiotic metabolic process GO:0006805 IDA
    estrogen metabolic process GO:0008210 IDA
    amine metabolic process GO:0009308 TAS
    flavonoid metabolic process GO:0009812 IDA
    3'-phosphoadenosine 5'-phosphosulfate metabolic process GO:0050427 IDA
    sulfation GO:0051923 IBA
    sulfation GO:0051923 IDA
    sulfation GO:0051923 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 ISS
    cytosol GO:0005829 TAS
 Experiment description of studies that identified SULT1A1 in sEVs
1
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SULT1A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STUB1 10273
Co-fractionation Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 ATP6V1B2 526
Co-fractionation Homo sapiens
4 ZRANB2 9406
Co-fractionation Homo sapiens
5 TRIP6 7205
Co-fractionation Homo sapiens
6 SULT1A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
8 ZPR1 8882
Co-fractionation Homo sapiens
9 TTC1 7265
Co-fractionation Homo sapiens
10 UBE2A  
Co-fractionation Homo sapiens
11 PGAM2 5224
Affinity Capture-MS Homo sapiens
12 COMMD4 54939
Co-fractionation Homo sapiens
13 COIL  
Proximity Label-MS Homo sapiens
14 DVL2 1856
Affinity Capture-MS Homo sapiens
15 STMN2  
Co-fractionation Homo sapiens
16 AHCYL1 10768
Co-fractionation Homo sapiens
17 SRXN1 140809
Co-fractionation Homo sapiens
18 THADA 63892
Co-fractionation Homo sapiens
19 TPM2 7169
Co-fractionation Homo sapiens
20 PFKM 5213
Co-fractionation Homo sapiens
21 SNCG 6623
Co-fractionation Homo sapiens
22 SULT1C3  
Affinity Capture-MS Homo sapiens
23 UBE4B 10277
Co-fractionation Homo sapiens
24 EGFR 1956
Affinity Capture-MS Homo sapiens
25 UCHL3 7347
Co-fractionation Homo sapiens
26 ZFYVE19 84936
Co-fractionation Homo sapiens
27 RCN1 5954
Co-fractionation Homo sapiens
28 TUBB6 84617
Co-fractionation Homo sapiens
29 SULT4A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 UBXN7 26043
Co-fractionation Homo sapiens
31 SULT1A3 6818
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TPM1 7168
Co-fractionation Homo sapiens
33 UBA2 10054
Co-fractionation Homo sapiens
34 RPA3 6119
Proximity Label-MS Homo sapiens
35 TMOD3 29766
Co-fractionation Homo sapiens
36 SSSCA1 10534
Co-fractionation Homo sapiens
37 TOM1L2 146691
Co-fractionation Homo sapiens
38 UBE2B 7320
Co-fractionation Homo sapiens
39 PTGES3 10728
Co-fractionation Homo sapiens
40 FOXR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 SMARCAL1  
Co-fractionation Homo sapiens
42 USP34 9736
Co-fractionation Homo sapiens
43 SULT1C2 6819
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 YAP1 10413
Co-fractionation Homo sapiens
45 STAM 8027
Co-fractionation Homo sapiens
46 PPM1G 5496
Co-fractionation Homo sapiens
47 TPM4 7171
Co-fractionation Homo sapiens
48 UBXN1 51035
Co-fractionation Homo sapiens
49 SULT2B1 6820
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
50 SUMO1 7341
Co-fractionation Homo sapiens
51 STAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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