Gene description for CAND2
Gene name cullin-associated and neddylation-dissociated 2 (putative)
Gene symbol CAND2
Other names/aliases TIP120B
Tp120b
Species Homo sapiens
 Database cross references - CAND2
ExoCarta ExoCarta_23066
Vesiclepedia VP_23066
Entrez Gene 23066
HGNC 30689
MIM 610403
UniProt O75155  
 CAND2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
Neuroblastoma cells 25944692    
 Gene ontology annotations for CAND2
Molecular Function
    protein binding GO:0005515 IPI
    TBP-class protein binding GO:0017025 IEA
Biological Process
    SCF complex assembly GO:0010265 IBA
    protein ubiquitination GO:0016567 IBA
    positive regulation of DNA-templated transcription GO:0045893 ISS
Subcellular Localization
    nucleus GO:0005634 IBA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified CAND2 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
6
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for CAND2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CA9 768
Affinity Capture-MS Homo sapiens
2 PSMA6 5687
Co-fractionation Homo sapiens
3 GRK5 2869
Affinity Capture-MS Homo sapiens
4 CUL1 8454
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 MLNR  
Affinity Capture-MS Homo sapiens
7 ALDH3A2 224
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 ARRDC4  
Affinity Capture-MS Homo sapiens
9 DNAJC15  
Affinity Capture-MS Homo sapiens
10 VTI1B 10490
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CXCR4 7852
Affinity Capture-MS Homo sapiens
12 GPR17 2840
Affinity Capture-MS Homo sapiens
13 SIGLECL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 BTNL9  
Affinity Capture-MS Homo sapiens
15 OPALIN  
Affinity Capture-MS Homo sapiens
16 CD83  
Affinity Capture-MS Homo sapiens
17 FZD10  
Affinity Capture-MS Homo sapiens
18 S100A6 6277
Affinity Capture-MS Homo sapiens
19 BSG 682
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 NPTN 27020
Affinity Capture-MS Homo sapiens
21 SYP  
Two-hybrid Homo sapiens
22 TPTE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 GLP1R  
PCA Homo sapiens
Affinity Capture-Western Homo sapiens
24 CHRM4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 EFNB1 1947
Affinity Capture-MS Homo sapiens
27 NPY2R  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 HTR2C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 DRG1 4733
Co-fractionation Homo sapiens
30 C5AR1  
Affinity Capture-MS Homo sapiens
31 PTGER3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TMEM108  
Affinity Capture-MS Homo sapiens
33 SDC2 6383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 HTR6  
Affinity Capture-MS Homo sapiens
35 UBE3C 9690
Biochemical Activity Homo sapiens
36 STOM 2040
Affinity Capture-MS Homo sapiens
37 CHRM3 1131
Affinity Capture-MS Homo sapiens
38 DLK2  
Affinity Capture-MS Homo sapiens
39 ARHGAP36  
Affinity Capture-MS Homo sapiens
40 ADORA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 GPR182  
Affinity Capture-MS Homo sapiens
42 FBXL6  
Affinity Capture-MS Homo sapiens
43 FAM174A 345757
Affinity Capture-MS Homo sapiens
44 CD244 51744
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PTPRN  
Affinity Capture-MS Homo sapiens
46 NAA15 80155
Co-fractionation Homo sapiens
47 CNOT3 4849
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
48 SCN2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 DNAJC1 64215
Affinity Capture-MS Homo sapiens
50 LPAR4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 P2RY10  
Affinity Capture-MS Homo sapiens
52 DDRGK1 65992
Affinity Capture-MS Homo sapiens
53 CIDEB  
Two-hybrid Homo sapiens
54 TNFSF13B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 SEMA4C 54910
Affinity Capture-MS Homo sapiens
56 EFNB2 1948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 SLAMF9  
Affinity Capture-MS Homo sapiens
58 FHL2 2274
Two-hybrid Homo sapiens
59 EPHA1 2041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 SEC62 7095
Affinity Capture-MS Homo sapiens
61 TACSTD2 4070
Affinity Capture-MS Homo sapiens
62 ITFG3 83986
Affinity Capture-MS Homo sapiens
63 UBE2D1 7321
Co-purification Homo sapiens
64 C9orf72  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CAND2 is involved
No pathways found





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