Gene description for PARP3
Gene name poly (ADP-ribose) polymerase family, member 3
Gene symbol PARP3
Other names/aliases ADPRT3
Species Homo sapiens
 Database cross references - PARP3
ExoCarta ExoCarta_10039
Entrez Gene 10039
HGNC 273
MIM 607726
UniProt Q9Y6F1  
 PARP3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for PARP3
Molecular Function
    catalytic activity GO:0003824 TAS
    NAD+ ADP-ribosyltransferase activity GO:0003950 IDA
Biological Process
    double-strand break repair GO:0006302 IMP
    telomere maintenance GO:0000723 IMP
    DNA repair GO:0006281 TAS
    positive regulation of DNA ligation GO:0051106 IGI
    protein ADP-ribosylation GO:0006471 IDA
    regulation of mitotic spindle organization GO:0060236 IMP
    protein localization to site of double-strand break GO:1990166 IMP
Subcellular Localization
    site of double-strand break GO:0035861 IDA
    centriole GO:0005814 IEA
    nucleus GO:0005634 IEA
 Experiment description of studies that identified PARP3 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PARP3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPA3  
Affinity Capture-MS Homo sapiens
2 MTHFD2 10797
Affinity Capture-MS Homo sapiens
3 PARP1 142
Affinity Capture-Western Homo sapiens
4 SWAP70 23075
Affinity Capture-MS Homo sapiens
5 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
6 HIST2H3C 126961
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PARP3 is involved
No pathways found

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