Gene description for WAS
Gene name	Wiskott-Aldrich syndrome
Gene symbol	WAS
Other names/aliases	IMD2 SCNX THC THC1 WASP WASPA
Species	Homo sapiens
Database cross references - WAS
ExoCarta	ExoCarta_7454
Vesiclepedia	VP_7454
Entrez Gene	7454
HGNC	12731
MIM	300392
UniProt	P42768
WAS identified in sEVs derived from the following tissue/cell type
B cells	20458337
B cells	20458337
B cells	20458337
Platelets	25332113
Platelets	25332113
Platelets	25332113

Gene ontology annotations for WAS

Molecular Function     actin binding GO:0003779 IEA     protein binding GO:0005515 IPI     SH3 domain binding GO:0017124 IPI     protein kinase binding GO:0019901 IPI     GTPase regulator activity GO:0030695 TAS     small GTPase binding GO:0031267 IPI     identical protein binding GO:0042802 IPI     phospholipase binding GO:0043274 IPI Biological Process     regulation of T cell antigen processing and presentation GO:0002625 IMP     defense response GO:0006952 TAS     immune response GO:0006955 IMP     Rho protein signal transduction GO:0007266 IMP     blood coagulation GO:0007596 TAS     regulation of actin polymerization or depolymerization GO:0008064 IMP     actin polymerization or depolymerization GO:0008154 TAS     epidermis development GO:0008544 TAS     regulation of lamellipodium assembly GO:0010591 IGI     endosomal transport GO:0016197 IEA     actin filament polymerization GO:0030041 IDA     actin filament-based movement GO:0030048 IEA     Cdc42 protein signal transduction GO:0032488 IMP     T cell activation GO:0042110 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     regulation of stress fiber assembly GO:0051492 IGI     negative regulation of stress fiber assembly GO:0051497 IMP     protein-containing complex assembly GO:0065003 TAS     cellular response to type II interferon GO:0071346 IEA     positive regulation of double-strand break repair via homologous recombination GO:1905168 IDA     negative regulation of cell motility GO:2000146 IMP     regulation of double-strand break repair via nonhomologous end joining GO:2001032 IDA Subcellular Localization     nucleus GO:0005634 IDA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS     actin filament GO:0005884 IDA     plasma membrane GO:0005886 IDA     cell-cell junction GO:0005911 IEA     vesicle membrane GO:0012506 IEA     actin cytoskeleton GO:0015629 TAS     site of double-strand break GO:0035861 IDA     phagocytic vesicle GO:0045335 IEA     extracellular exosome GO:0070062 HDA