Gene description for SOS2
Gene name son of sevenless homolog 2 (Drosophila)
Gene symbol SOS2
Other names/aliases -
Species Homo sapiens
 Database cross references - SOS2
ExoCarta ExoCarta_6655
Entrez Gene 6655
HGNC 11188
MIM 601247
UniProt Q07890  
 SOS2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SOS2
Molecular Function
    Rho guanyl-nucleotide exchange factor activity GO:0005089 IEA
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
    protein heterodimerization activity GO:0046982 IEA
Biological Process
    apoptotic signaling pathway GO:0097190 TAS
    positive regulation of apoptotic process GO:0043065 TAS
    regulation of small GTPase mediated signal transduction GO:0051056 TAS
    axon guidance GO:0007411 TAS
    positive regulation of GTPase activity GO:0043547 IEA
    small GTPase mediated signal transduction GO:0007264 TAS
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    positive regulation of small GTPase mediated signal transduction GO:0051057 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified SOS2 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SOS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GRAP2 9402
Reconstituted Complex Homo sapiens
2 ABI1 10006
Invivo Homo sapiens
3 PLCG1 5335
Invivo Homo sapiens
Two-hybrid Homo sapiens
4 EGFR 1956
Affinity Capture-Western Homo sapiens
5 GRB2 2885
Invivo Homo sapiens
Invivo Homo sapiens
6 SHC1 6464
Affinity Capture-Western Homo sapiens
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