Gene description for SGOL2
Gene name shugoshin-like 2 (S. pombe)
Gene symbol SGOL2
Other names/aliases SGO2
TRIPIN
Species Homo sapiens
 Database cross references - SGOL2
ExoCarta ExoCarta_151246
Vesiclepedia VP_151246
Entrez Gene 151246
HGNC 30812
MIM 612425
UniProt Q562F6  
 SGOL2 identified in sEVs derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for SGOL2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    chromosome segregation GO:0007059 IEA
    meiotic sister chromatid cohesion GO:0051177 IBA
    cell division GO:0051301 IEA
    meiotic cell cycle GO:0051321 IEA
Subcellular Localization
    chromosome, centromeric region GO:0000775 IDA
    kinetochore GO:0000776 IBA
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 TAS
    nuclear body GO:0016604 IDA
    mitotic cohesin complex GO:0030892 IDA
 Experiment description of studies that identified SGOL2 in sEVs
1
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for SGOL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD3EAP  
Proximity Label-MS Homo sapiens
2 CDCA8 55143
Two-hybrid Homo sapiens
3 TUSC2  
Affinity Capture-MS Homo sapiens
4 Sgol2  
Affinity Capture-MS Mus musculus
5 LYG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 FAM26D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SIRT6  
Affinity Capture-MS Homo sapiens
8 PARP1 142
Proximity Label-MS Homo sapiens
9 SPATS2L 26010
Affinity Capture-MS Homo sapiens
10 COIL  
Proximity Label-MS Homo sapiens
11 HEPHL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 EIF1AX 1964
Affinity Capture-MS Homo sapiens
13 RGN 9104
Affinity Capture-MS Homo sapiens
14 LRRC15 131578
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ALB 213
Affinity Capture-MS Homo sapiens
16 SERPINB13 5275
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 HIST1H2BJ 8970
Affinity Capture-MS Homo sapiens
18 IER2 9592
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 VSIG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 LYPLA2 11313
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 PREP 5550
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 H3F3B 3021
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 PKP1 5317
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 SERPINB5 5268
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 CENPA  
Proximity Label-MS Homo sapiens
26 DUSP14 11072
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 CAPZB 832
Affinity Capture-MS Homo sapiens
28 SLAIN2  
Two-hybrid Homo sapiens
29 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 PADI3 51702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 GNB2 2783
Affinity Capture-MS Homo sapiens
33 SELENBP1 8991
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 SET 6418
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
35 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
36 DSG4 147409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 WDR83  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 CSNK1E 1454
Affinity Capture-MS Homo sapiens
39 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 HSPA4 3308
Affinity Capture-MS Homo sapiens
41 S100B 6285
Affinity Capture-MS Homo sapiens
42 FEM1A  
Affinity Capture-MS Homo sapiens
43 PLP2 5355
Affinity Capture-MS Homo sapiens
44 HECTD1 25831
Affinity Capture-MS Homo sapiens
45 POLR1E  
Proximity Label-MS Homo sapiens
46 MAD2L1 4085
Affinity Capture-MS Homo sapiens
47 PPP2R5A 5525
Affinity Capture-MS Homo sapiens
48 PKP3 11187
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 HIST2H3PS2 440686
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 FBXO38 81545
Proximity Label-MS Homo sapiens
51 Set 56086
Affinity Capture-MS Mus musculus
52 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 ARL8B 55207
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 FANCD2  
Affinity Capture-MS Homo sapiens
55 EXOSC8  
Two-hybrid Homo sapiens
56 CASQ2 845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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