Gene description for SLC26A4
Gene name solute carrier family 26 (anion exchanger), member 4
Gene symbol SLC26A4
Other names/aliases DFNB4
EVA
PDS
TDH2B
Species Homo sapiens
 Database cross references - SLC26A4
ExoCarta ExoCarta_5172
Entrez Gene 5172
HGNC 8818
MIM 605646
UniProt O43511  
 SLC26A4 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
Urine 21082674    
Urine 22418980    
Urine 22418980    
 Gene ontology annotations for SLC26A4
Molecular Function
    sulfate transmembrane transporter activity GO:0015116 TAS
    chloride transmembrane transporter activity GO:0015108 IEA
    secondary active sulfate transmembrane transporter activity GO:0008271 IEA
    iodide transmembrane transporter activity GO:0015111 IEA
Biological Process
    chloride transmembrane transport GO:1902476 IEA
    iodide transport GO:0015705 IEA
    inorganic anion transport GO:0015698 TAS
    regulation of pH GO:0006885 ISS
    sensory perception of sound GO:0007605 TAS
    sulfate transmembrane transport GO:1902358 TAS
    regulation of protein localization GO:0032880 ISS
    sulfate transport GO:0008272 TAS
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    brush border membrane GO:0031526 ISS
    apical plasma membrane GO:0016324 ISS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified SLC26A4 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 102
ISEV standards
IEM
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21082674    
Organism Homo sapiens
Experiment description Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.
Authors Zhang Y, Li Y, Qiu F, Qiu Z.
Journal name ELEC
Publication year 2010
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Immunoelectron Microscopy
3
Experiment ID 196
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal high density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 197
ISEV standards
EM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 22418980    
Organism Homo sapiens
Experiment description A multiplex quantitative proteomics strategy for protein biomarker studies in urinary exosomes.
Authors Raj DA, Fiume I, Capasso G, Pocsfalvi G.
Journal name Kidney Int
Publication year 2012
Sample Urine
Sample name Urine - Normal low density
Isolation/purification methods Differential centrifugation
Sucrose cushion
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC26A4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC26A4 is involved
No pathways found





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