Gene description for CHST12
Gene name carbohydrate (chondroitin 4) sulfotransferase 12
Gene symbol CHST12
Other names/aliases C4S-2
C4ST-2
C4ST2
Species Homo sapiens
 Database cross references - CHST12
ExoCarta ExoCarta_55501
Entrez Gene 55501
HGNC 17423
MIM 610129
UniProt Q9NRB3  
 CHST12 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for CHST12
Molecular Function
    3'-phosphoadenosine 5'-phosphosulfate binding GO:0050656 NAS
    chondroitin 4-sulfotransferase activity GO:0047756 IDA
Biological Process
    carbohydrate metabolic process GO:0005975 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    chondroitin sulfate metabolic process GO:0030204 TAS
    chondroitin sulfate biosynthetic process GO:0030206 TAS
    carbohydrate biosynthetic process GO:0016051 IEA
    dermatan sulfate biosynthetic process GO:0030208 IDA
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    integral component of Golgi membrane GO:0030173 NAS
    Golgi membrane GO:0000139 TAS
    membrane GO:0016020 IDA
 Experiment description of studies that identified CHST12 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for CHST12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UGGT1 56886
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CHST12 is involved
PathwayEvidenceSource
Chondroitin sulfate biosynthesis TAS Reactome





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