Gene description for ZNF770
Gene name zinc finger protein 770
Gene symbol ZNF770
Other names/aliases PRO1914
Species Homo sapiens
 Database cross references - ZNF770
ExoCarta ExoCarta_54989
Vesiclepedia VP_54989
Entrez Gene 54989
HGNC 26061
UniProt Q6IQ21  
 ZNF770 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ZNF770
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IBA
    metal ion binding GO:0046872 IEA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
 Experiment description of studies that identified ZNF770 in exosomes
1
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ZNF770
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZNF668  
Affinity Capture-MS Homo sapiens
2 RPSAP58 388524
Affinity Capture-MS Homo sapiens
3 CACNG5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 RPS3A 6189
Affinity Capture-MS Homo sapiens
5 RPL30 6156
Affinity Capture-MS Homo sapiens
6 ZNF324B  
Affinity Capture-MS Homo sapiens
7 RPL13A 23521
Affinity Capture-MS Homo sapiens
8 RPL37A 6168
Affinity Capture-MS Homo sapiens
9 RPL14 9045
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 PNMAL1  
Affinity Capture-MS Homo sapiens
11 APP 351
Affinity Capture-MS Homo sapiens
12 RPL10A 4736
Affinity Capture-MS Homo sapiens
13 USP20  
Affinity Capture-MS Homo sapiens
14 LLPH  
Affinity Capture-MS Homo sapiens
15 UBE2O 63893
Affinity Capture-MS Homo sapiens
16 MPHOSPH8 54737
Affinity Capture-MS Homo sapiens
17 CCDC137  
Affinity Capture-MS Homo sapiens
18 RPS10 6204
Affinity Capture-MS Homo sapiens
19 NPM1 4869
Affinity Capture-MS Homo sapiens
20 H2AFY2 55506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 FGF17  
Affinity Capture-MS Homo sapiens
22 ZNF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 RPS9 6203
Affinity Capture-MS Homo sapiens
24 Set 56086
Affinity Capture-MS Mus musculus
25 ADARB1 104
Affinity Capture-MS Homo sapiens
26 PRKRA 8575
Affinity Capture-MS Homo sapiens
27 E4F1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 ZNF346  
Affinity Capture-MS Homo sapiens
29 TNFRSF1B  
Affinity Capture-MS Homo sapiens
30 RPL19 6143
Affinity Capture-MS Homo sapiens
31 RBM19 9904
Affinity Capture-MS Homo sapiens
32 LIN28A  
Affinity Capture-MS Homo sapiens
33 KLF16  
Proximity Label-MS Homo sapiens
34 MRPS25 64432
Affinity Capture-MS Homo sapiens
35 MCC 4163
Affinity Capture-MS Homo sapiens
36 RPL4 6124
Affinity Capture-MS Homo sapiens
37 MRPS34 65993
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 ZBTB47  
Affinity Capture-MS Homo sapiens
39 RBM4B  
Affinity Capture-MS Homo sapiens
40 APOBEC3C 27350
Affinity Capture-MS Homo sapiens
41 NOP2 4839
Affinity Capture-MS Homo sapiens
42 RPL18A 6142
Affinity Capture-MS Homo sapiens
43 RPL31 6160
Affinity Capture-MS Homo sapiens
44 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
45 RPL36 25873
Affinity Capture-MS Homo sapiens
46 RPL27A 6157
Affinity Capture-MS Homo sapiens
47 LYAR 55646
Affinity Capture-MS Homo sapiens
48 RPLP0 6175
Affinity Capture-MS Homo sapiens
49 MAGEB2 4113
Affinity Capture-MS Homo sapiens
50 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
51 CEBPA  
Proximity Label-MS Homo sapiens
52 RPL11 6135
Affinity Capture-MS Homo sapiens
53 WDR46  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 FGFBP1 9982
Affinity Capture-MS Homo sapiens
55 ABT1 29777
Affinity Capture-MS Homo sapiens
56 RPL7A 6130
Affinity Capture-MS Homo sapiens
57 RPS2 6187
Affinity Capture-MS Homo sapiens
58 RPL35 11224
Affinity Capture-MS Homo sapiens
59 TNFRSF1A 7132
Affinity Capture-MS Homo sapiens
60 SRSF5 6430
Affinity Capture-MS Homo sapiens
61 RPL3 6122
Affinity Capture-MS Homo sapiens
62 RPL7 6129
Affinity Capture-MS Homo sapiens
63 ZC3H10  
Affinity Capture-MS Homo sapiens
64 PRR3  
Affinity Capture-MS Homo sapiens
65 CUL9  
Affinity Capture-MS Homo sapiens
66 NOL12 79159
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 PPAN 56342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 RPL18 6141
Affinity Capture-MS Homo sapiens
69 MRPS17 51373
Affinity Capture-MS Homo sapiens
70 CCDC140  
Affinity Capture-MS Homo sapiens
71 RPL13 6137
Affinity Capture-MS Homo sapiens
72 SURF6  
Affinity Capture-MS Homo sapiens
73 ILF3 3609
Affinity Capture-MS Homo sapiens
74 TEX28  
Affinity Capture-MS Homo sapiens
75 DGCR8  
Affinity Capture-MS Homo sapiens
76 ZNF48  
Affinity Capture-MS Homo sapiens
77 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
78 ZNF490  
Affinity Capture-MS Homo sapiens
79 NIFK 84365
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 KRR1 11103
Affinity Capture-MS Homo sapiens
81 NEIL1  
Affinity Capture-MS Homo sapiens
82 MRPS18B 28973
Affinity Capture-MS Homo sapiens
83 GLI4  
Affinity Capture-MS Homo sapiens
84 RPS6 6194
Affinity Capture-MS Homo sapiens
85 RPL8 6132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 RPL28 6158
Affinity Capture-MS Homo sapiens
87 RPL23A 6147
Affinity Capture-MS Homo sapiens
88 ZNF467  
Affinity Capture-MS Homo sapiens
89 RPL17 6139
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ZNF770 is involved
PathwayEvidenceSource
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
RNA Polymerase II Transcription TAS Reactome





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