Gene description for SOD2
Gene name	superoxide dismutase 2, mitochondrial
Gene symbol	SOD2
Other names/aliases	IPOB MNSOD MVCD6
Species	Homo sapiens
Database cross references - SOD2
ExoCarta	ExoCarta_6648
Entrez Gene	6648
HGNC	11180
MIM	147460
UniProt	P04179
SOD2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for SOD2

Molecular Function     superoxide dismutase activity GO:0004784 TAS     manganese ion binding GO:0030145 TAS     oxygen binding GO:0019825 IEA     identical protein binding GO:0042802 IPI     DNA binding GO:0003677 IEA Biological Process     intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 IEA     negative regulation of neuron apoptotic process GO:0043524 IGI     vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure GO:0003069 ISS     respiratory electron transport chain GO:0022904 IEA     regulation of mitochondrial membrane potential GO:0051881 IEA     release of cytochrome c from mitochondria GO:0001836 ISS     glutathione metabolic process GO:0006749 IEA     superoxide metabolic process GO:0006801 IDA     detection of oxygen GO:0003032 IEA     positive regulation of nitric oxide biosynthetic process GO:0045429 IEA     response to silicon dioxide GO:0034021 IEA     response to hydrogen peroxide GO:0042542 IEA     erythrophore differentiation GO:0048773 IEA     hemopoiesis GO:0030097 IEA     locomotory behavior GO:0007626 IEA     response to manganese ion GO:0010042 IEA     response to superoxide GO:0000303 IMP     response to hyperoxia GO:0055093 IEA     response to drug GO:0042493 IEA     response to electrical stimulus GO:0051602 IEA     removal of superoxide radicals GO:0019430 IMP     response to activity GO:0014823 IEA     response to lipopolysaccharide GO:0032496 IEA     response to magnetism GO:0071000 IEA     hydrogen peroxide biosynthetic process GO:0050665 IEA     negative regulation of cell proliferation GO:0008285 IMP     cellular response to ethanol GO:0071361 IEA     regulation of blood pressure GO:0008217 ISS     post-embryonic development GO:0009791 IEA     neuron development GO:0048666 IEA     negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 IMP     negative regulation of fat cell differentiation GO:0045599 IEA     response to cold GO:0009409 IEA     liver development GO:0001889 IEA     heart development GO:0007507 IEA     response to L-ascorbic acid GO:0033591 IEA     response to gamma radiation GO:0010332 IEA     age-dependent response to reactive oxygen species GO:0001315 IMP     response to cadmium ion GO:0046686 IEA     protein homotetramerization GO:0051289 IPI     response to isolation stress GO:0035900 IEA     negative regulation of fibroblast proliferation GO:0048147 IEA     iron ion homeostasis GO:0055072 IEA     response to zinc ion GO:0010043 IEA     regulation of transcription from RNA polymerase II promoter GO:0006357 IMP     response to hypoxia GO:0001666 IEA     response to selenium ion GO:0010269 IEA     superoxide anion generation GO:0042554 IEA     response to reactive oxygen species GO:0000302 TAS     intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IEA     response to axon injury GO:0048678 IEA     oxygen homeostasis GO:0032364 IMP     response to immobilization stress GO:0035902 IEA     regulation of catalytic activity GO:0050790 IEA Subcellular Localization     mitochondrial matrix GO:0005759 TAS     mitochondrial nucleoid GO:0042645 IEA     mitochondrion GO:0005739 IDA     extracellular exosome GO:0070062 IDA     mitochondrial inner membrane GO:0005743 IEA