Gene description for DCAF6
Gene name DDB1 and CUL4 associated factor 6
Gene symbol DCAF6
Other names/aliases 1200006M05Rik
ARCAP
IQWD1
MSTP055
NRIP
PC326
Species Homo sapiens
 Database cross references - DCAF6
ExoCarta ExoCarta_55827
Entrez Gene 55827
HGNC 30002
MIM 610494
UniProt Q58WW2  
 DCAF6 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for DCAF6
Molecular Function
    ligand-dependent nuclear receptor transcription coactivator activity GO:0030374 IDA
Biological Process
    protein ubiquitination GO:0016567 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IGI
Subcellular Localization
    focal adhesion GO:0005925 IDA
    cytoplasm GO:0005737 IDA
    Cul4-RING E3 ubiquitin ligase complex GO:0080008 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified DCAF6 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for DCAF6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DCAF6 is involved
No pathways found





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