Gene description for RABEP1
Gene name rabaptin, RAB GTPase binding effector protein 1
Gene symbol RABEP1
Other names/aliases RAB5EP
RABPT5
Species Homo sapiens
 Database cross references - RABEP1
ExoCarta ExoCarta_9135
Vesiclepedia VP_9135
Entrez Gene 9135
HGNC 17677
MIM 603616
UniProt Q15276  
 RABEP1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RABEP1
Molecular Function
    GTPase activator activity GO:0005096 IEA
    protein binding GO:0005515 IPI
    growth factor activity GO:0008083 IEA
    protein domain specific binding GO:0019904 IPI
    protein homodimerization activity GO:0042803 IPI
Biological Process
    Golgi to plasma membrane transport GO:0006893 IBA
    Golgi to plasma membrane transport GO:0006893 ISS
    endocytosis GO:0006897 IEA
    apoptotic process GO:0006915 IEA
    signal transduction GO:0007165 IEA
    protein transport GO:0015031 IEA
    vesicle-mediated transport GO:0016192 IMP
    membrane fusion GO:0061025 TAS
    regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 IEA
    protein localization to ciliary membrane GO:1903441 ISS
Subcellular Localization
    endosome GO:0005768 IBA
    endosome GO:0005768 IDA
    early endosome GO:0005769 TAS
    endocytic vesicle GO:0030139 IBA
    endocytic vesicle GO:0030139 IDA
    early endosome membrane GO:0031901 TAS
    protein-containing complex GO:0032991 IMP
    intracellular membrane-bounded organelle GO:0043231 IDA
    recycling endosome GO:0055037 IEA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified RABEP1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RABEP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CLIP1 6249
Affinity Capture-MS Homo sapiens
2 RAB1A 5861
Reconstituted Complex Homo sapiens
3 CENPE 1062
Affinity Capture-MS Homo sapiens
4 SYCE1  
Affinity Capture-MS Homo sapiens
5 NRSN1  
Affinity Capture-MS Homo sapiens
6 YWHAE 7531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CCDC183  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 KIF20A 10112
Affinity Capture-MS Homo sapiens
9 GRIPAP1 56850
Affinity Capture-MS Homo sapiens
10 UBC 7316
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
11 TUFT1  
Affinity Capture-MS Homo sapiens
12 HSFY1  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
13 CAPZB 832
Co-fractionation Homo sapiens
14 EXOC1 55763
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 AP1G1 164
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
16 PSMD9 5715
Affinity Capture-MS Homo sapiens
17 YWHAG 7532
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RABEP1 9135
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
19 GGA1 26088
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
20 HERC2 8924
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 STX6 10228
Proximity Label-MS Homo sapiens
22 RGS9BP  
Affinity Capture-MS Homo sapiens
23 YWHAH 7533
Affinity Capture-MS Homo sapiens
24 VPS53 55275
Affinity Capture-MS Homo sapiens
25 PKN3 29941
Affinity Capture-MS Homo sapiens
26 LAMTOR1 55004
Proximity Label-MS Homo sapiens
27 EEA1 8411
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
28 YWHAB 7529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 C15orf59  
Affinity Capture-MS Homo sapiens
30 PFN1 5216
Proximity Label-MS Homo sapiens
31 RABGEF1 27342
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
32 KRT8 3856
Proximity Label-MS Homo sapiens
33 CLOCK  
Affinity Capture-MS Homo sapiens
34 RGS17  
Two-hybrid Homo sapiens
35 RABEP2 79874
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
36 TRIM26 7726
Two-hybrid Homo sapiens
37 RUFY1 80230
Co-fractionation Homo sapiens
38 SNAP91 9892
Affinity Capture-MS Homo sapiens
39 RAB21 23011
Affinity Capture-MS Homo sapiens
40 SMU1 55234
Co-fractionation Homo sapiens
41 FAM9C  
Affinity Capture-MS Homo sapiens
42 EXOC4 60412
Affinity Capture-MS Homo sapiens
43 RAB4A 5867
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
44 GIT2 9815
Affinity Capture-MS Homo sapiens
45 NTRK1 4914
Affinity Capture-MS Homo sapiens
46 SYNC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 PEX14 5195
Proximity Label-MS Homo sapiens
48 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 KRT2 3849
Affinity Capture-MS Homo sapiens
50 ACTR10 55860
Co-fractionation Homo sapiens
51 YEATS4  
Affinity Capture-MS Homo sapiens
52 NCKAP5L  
Affinity Capture-MS Homo sapiens
53 TCP10  
Affinity Capture-MS Homo sapiens
54 RABGEF1  
Two-hybrid Bos taurus
55 RAB5A 5868
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
56 CCDC186 55088
Affinity Capture-MS Homo sapiens
57 RAB11A 8766
Proximity Label-MS Homo sapiens
58 HERC2P9  
Affinity Capture-MS Homo sapiens
59 YWHAZ 7534
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 TFPT  
Affinity Capture-MS Homo sapiens
61 UACA 55075
Co-fractionation Homo sapiens
62 KRT27 342574
Affinity Capture-MS Homo sapiens
63 SGTB  
Affinity Capture-MS Homo sapiens
64 NEFL 4747
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
66 RAB9A 9367
Proximity Label-MS Homo sapiens
67 RABGAP1L 9910
Affinity Capture-MS Homo sapiens
68 PTPN23 25930
Proximity Label-MS Homo sapiens
69 KIAA0368 23392
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
70 TMEM74  
Affinity Capture-MS Homo sapiens
71 CCND1 595
Two-hybrid Homo sapiens
72 RPL26 6154
Cross-Linking-MS (XL-MS) Homo sapiens
73 DZIP3  
Affinity Capture-MS Homo sapiens
74 TRAF7  
Affinity Capture-MS Homo sapiens
75 GGA3 23163
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
76 TP53 7157
Affinity Capture-MS Homo sapiens
77 ITSN1 6453
Two-hybrid Homo sapiens
78 SLMAP 7871
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 HSF4  
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
80 PLEC 5339
Co-fractionation Homo sapiens
81 C15orf27  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 CCHCR1  
Affinity Capture-MS Homo sapiens
83 VPS52 6293
Affinity Capture-MS Homo sapiens
84 FOSL1  
Affinity Capture-MS Homo sapiens
85 SMARCC1 6599
Affinity Capture-MS Homo sapiens
86 ATXN7  
Two-hybrid Homo sapiens
87 SMURF1 57154
Biochemical Activity Homo sapiens
88 ACTR1B 10120
Co-fractionation Homo sapiens
89 DCTN2 10540
Co-fractionation Homo sapiens
90 GAP43  
Reconstituted Complex Homo sapiens
91 DDX58 23586
Affinity Capture-RNA Homo sapiens
92 NCAPD2 9918
Co-fractionation Homo sapiens
93 ITSN2 50618
Two-hybrid Homo sapiens
94 PSMA5 5686
Co-fractionation Homo sapiens
95 GOLGA5 9950
Affinity Capture-MS Homo sapiens
96 CLTA 1211
Proximity Label-MS Homo sapiens
97 KXD1 79036
Affinity Capture-MS Homo sapiens
98 RAB33B 83452
Reconstituted Complex Homo sapiens
99 GGA2 23062
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
100 SH3KBP1 30011
Affinity Capture-MS Homo sapiens
101 TMEM31  
Affinity Capture-MS Homo sapiens
102 RCOR1  
Affinity Capture-MS Homo sapiens
103 HUNK  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which RABEP1 is involved
PathwayEvidenceSource
Membrane Trafficking TAS Reactome
Rab regulation of trafficking TAS Reactome
TBC/RABGAPs TAS Reactome
Vesicle-mediated transport TAS Reactome





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