Gene description for DES
Gene name desmin
Gene symbol DES
Other names/aliases CSM1
CSM2
LGMD2R
Species Homo sapiens
 Database cross references - DES
ExoCarta ExoCarta_1674
Vesiclepedia VP_1674
Entrez Gene 1674
HGNC 2770
MIM 125660
UniProt P17661  
 DES identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Liver cancer cells 25265333    
 Gene ontology annotations for DES
Molecular Function
    structural constituent of cytoskeleton GO:0005200 IBA
    structural constituent of cytoskeleton GO:0005200 TAS
    protein binding GO:0005515 IPI
    cytoskeletal protein binding GO:0008092 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    muscle contraction GO:0006936 TAS
    nuclear envelope organization GO:0006998 ISS
    cytoskeleton organization GO:0007010 TAS
    regulation of heart contraction GO:0008016 TAS
    intermediate filament organization GO:0045109 IBA
    intermediate filament organization GO:0045109 IMP
    skeletal muscle organ development GO:0060538 IBA
Subcellular Localization
    nucleus GO:0005634 ISS
    nuclear envelope GO:0005635 ISS
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 TAS
    intermediate filament GO:0005882 IBA
    intermediate filament GO:0005882 IEA
    cell-cell junction GO:0005911 IBA
    fascia adherens GO:0005916 IEA
    intercalated disc GO:0014704 IDA
    Z disc GO:0030018 IBA
    Z disc GO:0030018 IDA
    neuromuscular junction GO:0031594 IEA
    sarcolemma GO:0042383 IBA
    sarcolemma GO:0042383 IDA
    intermediate filament cytoskeleton GO:0045111 IDA
    cell tip GO:0051286 ISS
    extracellular exosome GO:0070062 HDA
    cardiac myofibril GO:0097512 IDA
 Experiment description of studies that identified DES in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 267
MISEV standards
✘ Biophysical techniques
✔
TSG101|Alix
Enriched markers
✔
CANX|HSP90B1
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25265333    
Organism Homo sapiens
Experiment description Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS
Authors "Zhao X, Wu Y, Duan J, Ma Y, Shen Z, Wei L, Cui X, Zhang J, Xie Y, Liu J"
Journal name J Proteome Res
Publication year 2014
Sample Liver cancer cells
Sample name Huh-7 - Transfected with HBx plasmids
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for DES
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POLR2G 5436
Two-hybrid Homo sapiens
2 ZMYM5 9205
Two-hybrid Homo sapiens
3 KRT37 8688
Two-hybrid Homo sapiens
4 KRT73 319101
Affinity Capture-MS Homo sapiens
5 PMPCA 23203
Affinity Capture-MS Homo sapiens
6 KRT76 51350
Cross-Linking-MS (XL-MS) Homo sapiens
7 SPRTN  
Affinity Capture-MS Homo sapiens
8 KRT6B 3854
Cross-Linking-MS (XL-MS) Homo sapiens
9 KRT1 3848
Cross-Linking-MS (XL-MS) Homo sapiens
10 SYCE1  
Affinity Capture-MS Homo sapiens
11 KRT6A 3853
Cross-Linking-MS (XL-MS) Homo sapiens
12 KRT17 3872
Cross-Linking-MS (XL-MS) Homo sapiens
13 SP1  
Affinity Capture-MS Homo sapiens
14 GFAP 2670
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ADSSL1  
Affinity Capture-MS Homo sapiens
16 DTNA  
Affinity Capture-MS Homo sapiens
17 KIF20A 10112
Affinity Capture-MS Homo sapiens
18 CT55  
Two-hybrid Homo sapiens
19 TRIM55  
Two-hybrid Homo sapiens
20 CCDC92  
Affinity Capture-MS Homo sapiens
21 PPP1R18 170954
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 PPL 5493
Two-hybrid Homo sapiens
23 SNRNP70 6625
Co-fractionation Homo sapiens
24 KIF23 9493
Affinity Capture-MS Homo sapiens
25 LONRF3  
Two-hybrid Homo sapiens
26 LENG1  
Two-hybrid Homo sapiens
27 MRPS5 64969
Affinity Capture-MS Homo sapiens
28 PRC1 9055
Affinity Capture-MS Homo sapiens
29 ERC1 23085
Affinity Capture-MS Homo sapiens
30 KRT5 3852
Cross-Linking-MS (XL-MS) Homo sapiens
31 RTN1 6252
Affinity Capture-MS Homo sapiens
32 RPL29 6159
Co-fractionation Homo sapiens
33 KRT72 140807
Cross-Linking-MS (XL-MS) Homo sapiens
34 DDX6 1656
Two-hybrid Homo sapiens
35 RPL34 6164
Affinity Capture-MS Homo sapiens
36 PMPCB 9512
Affinity Capture-MS Homo sapiens
37 SYNM 23336
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
38 SOD1 6647
Affinity Capture-MS Homo sapiens
39 LMO4  
Two-hybrid Homo sapiens
40 YES1 7525
Two-hybrid Homo sapiens
41 KIF14 9928
Affinity Capture-MS Homo sapiens
42 C1orf216  
Two-hybrid Homo sapiens
43 GOLGA6L9  
Two-hybrid Homo sapiens
44 BAG5 9529
Two-hybrid Homo sapiens
45 KRT8 3856
Cross-Linking-MS (XL-MS) Homo sapiens
46 KRT12 3859
Cross-Linking-MS (XL-MS) Homo sapiens
47 SPATA24  
Affinity Capture-MS Homo sapiens
48 NEB 4703
Two-hybrid Homo sapiens
49 TSPAN33 340348
Affinity Capture-MS Homo sapiens
50 PRPH 5630
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
51 USP11 8237
Affinity Capture-MS Homo sapiens
52 TCEA2  
Two-hybrid Homo sapiens
53 CCT7 10574
Co-fractionation Homo sapiens
54 RSPH6A  
Affinity Capture-MS Homo sapiens
55 UBE2I 7329
Two-hybrid Homo sapiens
56 ITSN1 6453
Two-hybrid Homo sapiens
57 CARM1 10498
Affinity Capture-MS Homo sapiens
58 CHMP4B 128866
Affinity Capture-MS Homo sapiens
59 VCP 7415
Co-fractionation Homo sapiens
60 SYNC  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 KRT75 9119
Two-hybrid Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
62 KRT14 3861
Cross-Linking-MS (XL-MS) Homo sapiens
63 YWHAQ 10971
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
64 KRT2 3849
Cross-Linking-MS (XL-MS) Homo sapiens
65 SLC47A1  
Affinity Capture-MS Homo sapiens
66 TRIM63  
Two-hybrid Homo sapiens
67 BRCA1 672
Two-hybrid Homo sapiens
68 SPATA22  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 ANLN 54443
Affinity Capture-MS Homo sapiens
70 GAN 8139
Affinity Capture-MS Homo sapiens
71 KRT3 3850
Cross-Linking-MS (XL-MS) Homo sapiens
72 HADHB 3032
Co-fractionation Homo sapiens
73 CDC73  
Affinity Capture-MS Homo sapiens
74 KRT33B 3884
Two-hybrid Homo sapiens
75 ECT2 1894
Affinity Capture-MS Homo sapiens
76 CRYAB 1410
Reconstituted Complex Homo sapiens
77 NUP88 4927
Affinity Capture-MS Homo sapiens
78 DES 1674
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
79 GLI1  
Affinity Capture-MS Homo sapiens
80 HSP90AA5P 730211
Co-fractionation Homo sapiens
81 HNRNPUL1 11100
Co-fractionation Homo sapiens
82 PLEKHA5 54477
Two-hybrid Homo sapiens
83 AURKB 9212
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
84 KRT15 3866
Two-hybrid Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
85 ABTB2 25841
Affinity Capture-MS Homo sapiens
86 PCBP1 5093
Proximity Label-MS Homo sapiens
87 BMPR2 659
Affinity Capture-MS Homo sapiens
88 NEFM 4741
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 DLST 1743
Affinity Capture-MS Homo sapiens
90 KRT84 3890
Cross-Linking-MS (XL-MS) Homo sapiens
91 MECOM 2122
Affinity Capture-MS Homo sapiens
92 KRT19 3880
Cross-Linking-MS (XL-MS) Homo sapiens
93 KRT16 3868
Cross-Linking-MS (XL-MS) Homo sapiens
94 DSP 1832
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
95 NES 10763
Affinity Capture-MS Homo sapiens
96 NSF 4905
Affinity Capture-MS Homo sapiens
97 MAPKAPK2 9261
Two-hybrid Homo sapiens
98 SPTAN1 6709
Co-purification Homo sapiens
99 MYL6 4637
Co-fractionation Homo sapiens
100 SHBG 6462
Two-hybrid Homo sapiens
101 JUP 3728
Co-fractionation Homo sapiens
102 RAB27B 5874
Affinity Capture-MS Homo sapiens
103 KRT10 3858
Cross-Linking-MS (XL-MS) Homo sapiens
104 EHHADH 1962
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
105 NEK6 10783
Two-hybrid Homo sapiens
106 PDHA1 5160
Affinity Capture-MS Homo sapiens
107 KRT77 374454
Cross-Linking-MS (XL-MS) Homo sapiens
108 HSPB1 3315
Two-hybrid Homo sapiens
109 MLH1 4292
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
110 CWF19L2  
Two-hybrid Homo sapiens
111 LATS1  
Affinity Capture-MS Homo sapiens
112 KRT6C 286887
Cross-Linking-MS (XL-MS) Homo sapiens
113 PIH1D2  
Two-hybrid Homo sapiens
114 LBX1  
Two-hybrid Homo sapiens
115 MOV10 4343
Affinity Capture-RNA Homo sapiens
116 KRT20 54474
Two-hybrid Homo sapiens
117 INA 9118
Affinity Capture-MS Homo sapiens
118 RPL17 6139
Co-fractionation Homo sapiens
119 M1AP  
Two-hybrid Homo sapiens
120 KLHL22 84861
Affinity Capture-MS Homo sapiens
121 KRT13 3860
Two-hybrid Homo sapiens
122 NEFL 4747
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
123 S100A1 6271
Reconstituted Complex Homo sapiens
124 KIF1C 10749
Affinity Capture-MS Homo sapiens
125 VIM 7431
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 RNF214  
Affinity Capture-MS Homo sapiens
127 CUL4A 8451
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DES is involved
PathwayEvidenceSource
Muscle contraction TAS Reactome
Striated Muscle Contraction TAS Reactome





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