Experiment description of studies that identified SCRN2 in sEVs

1 Experiment ID 488 MISEV standards ✔ EM Biophysical techniques ✔ CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82 Enriched markers ✔ CANX Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 36408942     Organism Homo sapiens Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ." Journal name Proteomics Publication year 2023 Sample Mesenchymal stem cells Sample name UCMSC Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Western blotting Mass spectometry

2 Experiment ID 211 MISEV standards ✔ EM Biophysical techniques ✔ TSG101|Alix|EpCAM|TFRC Enriched markers ✔ cytochrome c|GOLGA2 Negative markers ✘ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23333927     Organism Homo sapiens Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes. Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K." Journal name J Proteomics Publication year 2013 Sample Ovarian cancer cells Sample name IGROV1 Isolation/purification methods Differential centrifugation Ultracentrifugation Sucrose density gradient Flotation density 1.09-1.15 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry

3 Experiment ID 212 MISEV standards ✔ CEM Biophysical techniques ✔ TSG101|Alix|EpCAM|TFRC Enriched markers ✔ Cytochrome C|GOLGA2 Negative markers ✘ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23333927     Organism Homo sapiens Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes. Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K." Journal name J Proteomics Publication year 2013 Sample Ovarian cancer cells Sample name OVCAR-3 Isolation/purification methods Differential centrifugation Ultracentrifugation Sucrose density gradient Flotation density 1.09-1.15 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry

4 Experiment ID 63 MISEV standards ✘ Biophysical techniques ✔ AQP2 Enriched markers ✘ Negative markers ✘ Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 19056867     Organism Homo sapiens Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes. Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA" Journal name JASN Publication year 2009 Sample Urine Sample name Urine - Normal Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ] Western blotting

Protein-protein interactions for SCRN2

Protein Interactor ExoCarta ID Identification method PubMed Species 1 DBF4B 80174 Affinity Capture-MS Homo sapiens 2 SCRN1 9805 Affinity Capture-MS Homo sapiens 3 XYLB 9942 Co-fractionation Homo sapiens 4 TAS2R41   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 5 NFKBIA   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 6 IFI30   Affinity Capture-MS Homo sapiens 7 TERF2IP 54386 Two-hybrid Homo sapiens 8 PDPK1 5170 Affinity Capture-MS Homo sapiens 9 PRRC2B   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 10 XRN1 54464 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 11 FAM122B   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 12 DCAF10   Affinity Capture-MS Homo sapiens 13 CCS 9973 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 14 HARS2 23438 Co-fractionation Homo sapiens 15 KAT5   Two-hybrid Homo sapiens 16 MEOX2   Two-hybrid Homo sapiens 17 LDLR 3949 Positive Genetic Homo sapiens 18 PEX5 5830 Two-hybrid Homo sapiens 19 CAMK2D 817 Affinity Capture-MS Homo sapiens 20 TINF2   Two-hybrid Homo sapiens 21 KCTD3   Affinity Capture-MS Homo sapiens 22 TOM1L1 10040 Co-fractionation Homo sapiens 23 SOX2   Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens 24 MARCKSL1 65108 Affinity Capture-MS Homo sapiens Affinity Capture-MS Homo sapiens View the network

Pathways in which SCRN2 is involved

No pathways found