Gene description for CLGN
Gene name calmegin
Gene symbol CLGN
Other names/aliases -
Species Homo sapiens
 Database cross references - CLGN
ExoCarta ExoCarta_1047
Vesiclepedia VP_1047
Entrez Gene 1047
HGNC 2060
MIM 601858
UniProt O14967  
 CLGN identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for CLGN
Molecular Function
    calcium ion binding GO:0005509 IBA
    protein folding chaperone GO:0044183 IEA
    unfolded protein binding GO:0051082 IEA
Biological Process
    protein folding GO:0006457 IBA
    single fertilization GO:0007338 TAS
    binding of sperm to zona pellucida GO:0007339 IEA
    ERAD pathway GO:0036503 IBA
    protein-containing complex assembly GO:0065003 IEA
Subcellular Localization
    nuclear envelope GO:0005635 IEA
    endoplasmic reticulum GO:0005783 IDA
    endoplasmic reticulum membrane GO:0005789 IBA
 Experiment description of studies that identified CLGN in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CLGN
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BRINP2  
Affinity Capture-MS Homo sapiens
2 POMT2  
Affinity Capture-MS Homo sapiens
3 ARSK  
Affinity Capture-MS Homo sapiens
4 RAMP3  
Affinity Capture-MS Homo sapiens
5 GJD3  
Proximity Label-MS Homo sapiens
6 ENPP4 22875
Affinity Capture-MS Homo sapiens
7 DPY19L4  
Affinity Capture-MS Homo sapiens
8 KPNA3 3839
Co-fractionation Homo sapiens
9 TOR1A 1861
Affinity Capture-MS Homo sapiens
10 CACNA2D1 781
Affinity Capture-MS Homo sapiens
11 RAB1A 5861
Co-fractionation Homo sapiens
12 CD3D 915
Affinity Capture-MS Homo sapiens
13 TTYH3 80727
Affinity Capture-MS Homo sapiens
14 GCNT1  
Affinity Capture-MS Homo sapiens
15 ADRB2  
Affinity Capture-MS Homo sapiens
16 ARSB 411
Affinity Capture-MS Homo sapiens
17 TMEM95  
Affinity Capture-MS Homo sapiens
18 ECEL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 HSD17B11 51170
Proximity Label-MS Homo sapiens
20 LRIG3  
Affinity Capture-MS Homo sapiens
21 LAMP2 3920
Proximity Label-MS Homo sapiens
22 TMEM67 91147
Affinity Capture-MS Homo sapiens
23 KLRB1  
Affinity Capture-MS Homo sapiens
24 SLC22A9  
Affinity Capture-MS Homo sapiens
25 H2AFV 94239
Cross-Linking-MS (XL-MS) Homo sapiens
26 AMIGO1  
Affinity Capture-MS Homo sapiens
27 HYAL1 3373
Affinity Capture-MS Homo sapiens
28 PIGN 23556
Affinity Capture-MS Homo sapiens
29 ITGA7 3679
Affinity Capture-MS Homo sapiens
30 CHST12 55501
Affinity Capture-MS Homo sapiens
31 PKD2 5311
Affinity Capture-MS Homo sapiens
32 CARKD 55739
Affinity Capture-MS Homo sapiens
33 IGSF8 93185
Affinity Capture-MS Homo sapiens
34 ATP1B2  
Affinity Capture-MS Homo sapiens
35 TOR1AIP1 26092
Affinity Capture-MS Homo sapiens
36 HYAL2 8692
Affinity Capture-MS Homo sapiens
37 CLEC2B  
Affinity Capture-MS Homo sapiens
38 KLRC1  
Affinity Capture-MS Homo sapiens
39 ST8SIA5  
Affinity Capture-MS Homo sapiens
40 AMIGO3  
Affinity Capture-MS Homo sapiens
41 CD276 80381
Affinity Capture-MS Homo sapiens
42 PRELP 5549
Affinity Capture-MS Homo sapiens
43 SLC12A6 9990
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 SCARB1 949
Affinity Capture-MS Homo sapiens
45 ENPP1 5167
Affinity Capture-MS Homo sapiens
46 ADAM1A  
Affinity Capture-Western Homo sapiens
47 TMTC4  
Affinity Capture-MS Homo sapiens
48 SMPD1 6609
Affinity Capture-MS Homo sapiens
49 TOR3A 64222
Affinity Capture-MS Homo sapiens
50 ADAM2  
Affinity Capture-Western Homo sapiens
51 KLRC2  
Affinity Capture-MS Homo sapiens
52 MAN2B2 23324
Affinity Capture-MS Homo sapiens
53 SSR1 6745
Proximity Label-MS Homo sapiens
54 SLC12A7 10723
Affinity Capture-MS Homo sapiens
55 TMEM2 23670
Affinity Capture-MS Homo sapiens
56 ATP6AP1 537
Affinity Capture-MS Homo sapiens
57 KIF14 9928
Affinity Capture-MS Homo sapiens
58 SLC44A5  
Affinity Capture-MS Homo sapiens
59 ITLN1 55600
Affinity Capture-MS Homo sapiens
60 ABCC5 10057
Affinity Capture-MS Homo sapiens
61 TAZ  
Affinity Capture-MS Homo sapiens
62 SLC30A1 7779
Affinity Capture-MS Homo sapiens
63 H2AFZ 3015
Cross-Linking-MS (XL-MS) Homo sapiens
64 SMO 6608
Affinity Capture-MS Homo sapiens
65 DPEP2  
Affinity Capture-MS Homo sapiens
66 TOR1B 27348
Affinity Capture-MS Homo sapiens
67 NPC1 4864
Affinity Capture-MS Homo sapiens
68 HSP90B1 7184
Co-fractionation Homo sapiens
69 TSPAN3 10099
Affinity Capture-MS Homo sapiens
70 TMEM219  
Affinity Capture-MS Homo sapiens
71 LYZL6  
Affinity Capture-MS Homo sapiens
72 KPNA4 3840
Co-fractionation Homo sapiens
73 KDSR 2531
Co-fractionation Homo sapiens
74 C12orf49  
Affinity Capture-MS Homo sapiens
75 ACP5  
Affinity Capture-MS Homo sapiens
76 MAN2A2 4122
Affinity Capture-MS Homo sapiens
77 VCP 7415
Co-fractionation Homo sapiens
78 NTRK1 4914
Affinity Capture-MS Homo sapiens
79 XK  
Two-hybrid Homo sapiens
80 APMAP 57136
Co-fractionation Homo sapiens
81 DNAJA1 3301
Co-fractionation Homo sapiens
82 GML  
Affinity Capture-MS Homo sapiens
83 RPN1 6184
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
84 PCSK9 255738
Affinity Capture-MS Homo sapiens
85 GALNS 2588
Affinity Capture-MS Homo sapiens
86 SLC12A4 6560
Affinity Capture-MS Homo sapiens
87 CD63 967
Affinity Capture-MS Homo sapiens
88 PGAP1 80055
Affinity Capture-MS Homo sapiens
89 HYAL3  
Affinity Capture-MS Homo sapiens
90 SEC61B 10952
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 UST  
Affinity Capture-MS Homo sapiens
92 LRRC8A 56262
Affinity Capture-MS Homo sapiens
93 SLC4A2 6522
Affinity Capture-MS Homo sapiens
94 FBXL4 26235
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
95 ARSA 410
Affinity Capture-MS Homo sapiens
96 MBTPS1 8720
Affinity Capture-MS Homo sapiens
97 BCAP31 10134
Proximity Label-MS Homo sapiens
98 TMPO 7112
Affinity Capture-MS Homo sapiens
99 ANO6 196527
Affinity Capture-MS Homo sapiens
100 TMEM30A 55754
Affinity Capture-MS Homo sapiens
101 NDST2  
Affinity Capture-MS Homo sapiens
102 RPN2 6185
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
103 CUL3 8452
Affinity Capture-MS Homo sapiens
104 CANX 821
Affinity Capture-MS Homo sapiens
105 KDM4D  
Affinity Capture-MS Homo sapiens
106 LRRC59 55379
Proximity Label-MS Homo sapiens
107 PLD6  
Affinity Capture-MS Homo sapiens
108 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
109 ATP2B1 490
Co-fractionation Homo sapiens
110 ADCY9 115
Affinity Capture-MS Homo sapiens
111 SARM1 23098
Affinity Capture-MS Homo sapiens
112 CHST8 64377
Affinity Capture-MS Homo sapiens
113 CNTNAP1 8506
Affinity Capture-MS Homo sapiens
114 B3GNT3 10331
Affinity Capture-MS Homo sapiens
115 GPC3 2719
Affinity Capture-MS Homo sapiens
116 SLC22A5 6584
Affinity Capture-MS Homo sapiens
117 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
118 SLCO4C1 353189
Affinity Capture-MS Homo sapiens
119 KLRD1  
Affinity Capture-MS Homo sapiens
120 GAA 2548
Affinity Capture-MS Homo sapiens
121 EPRS 2058
Co-fractionation Homo sapiens
122 FAM187B  
Affinity Capture-MS Homo sapiens
123 TCTN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 RCN1 5954
Co-fractionation Homo sapiens
125 ECE1 1889
Affinity Capture-MS Homo sapiens
126 GCNT2 2651
Affinity Capture-MS Homo sapiens
127 PLTP 5360
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 LNPEP 4012
Affinity Capture-MS Homo sapiens
129 CHRNA5  
Affinity Capture-MS Homo sapiens
130 TMEM237 65062
Affinity Capture-MS Homo sapiens
131 LRIG1 26018
Affinity Capture-MS Homo sapiens
132 ATP2A1 487
Proximity Label-MS Homo sapiens
133 ALDH3B2  
Affinity Capture-MS Homo sapiens
134 A4GNT  
Affinity Capture-MS Homo sapiens
135 ABCC1 4363
Co-fractionation Homo sapiens
136 MPZL1 9019
Affinity Capture-MS Homo sapiens
137 MET 4233
Affinity Capture-MS Homo sapiens
138 GXYLT1 283464
Affinity Capture-MS Homo sapiens
139 A4GALT  
Affinity Capture-MS Homo sapiens
140 ENTPD2 954
Affinity Capture-MS Homo sapiens
141 PCYOX1L 78991
Affinity Capture-MS Homo sapiens
142 PTPRU  
Affinity Capture-MS Homo sapiens
143 POGLUT1 56983
Affinity Capture-MS Homo sapiens
144 TMPRSS5  
Affinity Capture-MS Homo sapiens
145 ST3GAL6 10402
Affinity Capture-MS Homo sapiens
146 SLC9A6 10479
Affinity Capture-MS Homo sapiens
147 ALG9 79796
Affinity Capture-MS Homo sapiens
148 UGT8  
Affinity Capture-MS Homo sapiens
149 SLC12A2 6558
Affinity Capture-MS Homo sapiens
150 ATP2B3 492
Co-fractionation Homo sapiens
151 ST3GAL5  
Affinity Capture-MS Homo sapiens
152 SEL1L3  
Affinity Capture-MS Homo sapiens
153 HMGCR  
Affinity Capture-MS Homo sapiens
154 FCGR3B  
Affinity Capture-MS Homo sapiens
155 HLA-DMB 3109
Affinity Capture-MS Homo sapiens
156 COLEC12 81035
Affinity Capture-MS Homo sapiens
157 ABCA2 20
Affinity Capture-MS Homo sapiens
158 ATP2B4 493
Co-fractionation Homo sapiens
159 FOXRED2  
Affinity Capture-MS Homo sapiens
160 TXNDC15  
Affinity Capture-MS Homo sapiens
161 LDLRAD1  
Affinity Capture-MS Homo sapiens
162 PIEZO1 9780
Affinity Capture-MS Homo sapiens
163 CALU 813
Co-fractionation Homo sapiens
164 TNFSF14  
Affinity Capture-MS Homo sapiens
165 CLPTM1 1209
Affinity Capture-MS Homo sapiens
166 LINC00839  
Protein-RNA Homo sapiens
167 SCARB2 950
Affinity Capture-MS Homo sapiens
168 CLEC4C  
Affinity Capture-MS Homo sapiens
169 RPS5 6193
Co-fractionation Homo sapiens
170 APOM 55937
Affinity Capture-MS Homo sapiens
171 NAGLU 4669
Affinity Capture-MS Homo sapiens
172 IL6ST 3572
Affinity Capture-MS Homo sapiens
173 TLR9  
Affinity Capture-MS Homo sapiens
174 ATF6B  
Affinity Capture-MS Homo sapiens
175 OGFOD3 79701
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
176 GDE1 51573
Two-hybrid Homo sapiens
177 PLD3 23646
Affinity Capture-MS Homo sapiens
178 CACNA2D2 9254
Affinity Capture-MS Homo sapiens
179 SEC62 7095
Proximity Label-MS Homo sapiens
180 SPPL2B 56928
Affinity Capture-MS Homo sapiens
181 UGT1A7 54577
Affinity Capture-MS Homo sapiens
182 LIPA 3988
Affinity Capture-MS Homo sapiens
183 NCEH1 57552
Affinity Capture-MS Homo sapiens
184 LMLN  
Affinity Capture-MS Homo sapiens
185 WFS1 7466
Affinity Capture-MS Homo sapiens
186 CNR2  
Affinity Capture-MS Homo sapiens
187 PTCH1  
Affinity Capture-MS Homo sapiens
188 CLEC4E  
Affinity Capture-MS Homo sapiens
189 CHRNA3 1136
Affinity Capture-MS Homo sapiens
190 SEC61A1 29927
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which CLGN is involved
No pathways found





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