Gene description for Mki67
Gene name antigen identified by monoclonal antibody Ki 67
Gene symbol Mki67
Other names/aliases D630048A14Rik
Ki-67
Ki67
Species Mus musculus
 Database cross references - Mki67
ExoCarta ExoCarta_17345
Vesiclepedia VP_17345
Entrez Gene 17345
 Mki67 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Mki67
Molecular Function
    DNA binding GO:0003677 IEA
    RNA binding GO:0003723 ISS
    ATP binding GO:0005524 IEA
    molecular condensate scaffold activity GO:0140693 ISS
Biological Process
    chromosome segregation GO:0007059 ISS
    regulation of mitotic nuclear division GO:0007088 IBA
    regulation of mitotic nuclear division GO:0007088 ISO
    regulation of mitotic nuclear division GO:0007088 ISS
    cell population proliferation GO:0008283 IDA
    cell population proliferation GO:0008283 IMP
    epithelial cell proliferation GO:0050673 IDA
    meiotic cell cycle GO:0051321 IDA
    regulation of chromosome segregation GO:0051983 IBA
    regulation of chromosome segregation GO:0051983 ISO
    stem cell proliferation GO:0072089 IDA
    hepatocyte proliferation GO:0072574 IDA
    regulation of chromatin organization GO:1902275 IMP
    cholangiocyte proliferation GO:1990705 IDA
Subcellular Localization
    chromosome, centromeric region GO:0000775 IDA
    condensed chromosome GO:0000793 IDA
    condensed chromosome GO:0000793 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 ISO
    chromosome GO:0005694 IBA
    chromosome GO:0005694 ISO
    nucleolus GO:0005730 IDA
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 IDA
    nuclear body GO:0016604 ISO
 Experiment description of studies that identified Mki67 in sEVs
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Mki67
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RSL1D1 26156
Affinity Capture-MS Homo sapiens
2 Elf5  
Affinity Capture-MS Mus musculus
3 SFPQ 6421
Affinity Capture-MS Homo sapiens
4 KPNA3 3839
Affinity Capture-MS Homo sapiens
5 Aspm  
Co-fractionation Mus musculus
6 Fbxo5  
Co-fractionation Mus musculus
7 KPNA1 3836
Affinity Capture-MS Homo sapiens
8 MRTO4 51154
Affinity Capture-MS Homo sapiens
9 Cenpk  
Co-fractionation Mus musculus
10 PPP1CC 5501
Affinity Capture-MS Homo sapiens
11 KPNB1 3837
Affinity Capture-MS Homo sapiens
12 KPNA6 23633
Affinity Capture-MS Homo sapiens
13 KPNA2 3838
Affinity Capture-MS Homo sapiens
14 Ncaph  
Co-fractionation Mus musculus
15 MKI67  
Affinity Capture-MS Homo sapiens
16 NIFK 84365
Affinity Capture-MS Homo sapiens
17 NONO 4841
Affinity Capture-MS Homo sapiens
18 Tmem173  
Proximity Label-MS Mus musculus
19 NOP2 4839
Affinity Capture-MS Homo sapiens
20 KPNA4 3840
Affinity Capture-MS Homo sapiens
21 Plk4  
Co-fractionation Mus musculus
22 NUP50 10762
Affinity Capture-MS Homo sapiens
23 CDH1 999
Biochemical Activity Homo sapiens
24 NUP153 9972
Affinity Capture-MS Homo sapiens
25 Smc2 14211
Co-fractionation Mus musculus
26 Cenpe  
Co-fractionation Mus musculus
27 Fancd2  
Affinity Capture-MS Mus musculus
28 Kif23 71819
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Mki67 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here