Gene description for EFEMP2
Gene name EGF containing fibulin-like extracellular matrix protein 2
Gene symbol EFEMP2
Other names/aliases ARCL1B
FBLN4
MBP1
UPH1
Species Homo sapiens
 Database cross references - EFEMP2
ExoCarta ExoCarta_30008
Entrez Gene 30008
HGNC 3219
MIM 604633
UniProt O95967  
 EFEMP2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Saliva 19199708    
 Gene ontology annotations for EFEMP2
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    extracellular matrix structural constituent GO:0005201 TAS
Biological Process
    extracellular matrix organization GO:0030198 TAS
Subcellular Localization
    extracellular vesicle GO:1903561 IDA
    extracellular exosome GO:0070062 IDA
    basement membrane GO:0005604 TAS
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified EFEMP2 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 66
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for EFEMP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FLJ22746  
Two-hybrid Homo sapiens
2 HHEX  
Two-hybrid Homo sapiens
3 HOXA1  
Two-hybrid Homo sapiens
4 LRDD  
Two-hybrid Homo sapiens
5 TCAF1 9747
Two-hybrid Homo sapiens
6 AQP1 358
Two-hybrid Homo sapiens
7 PLSCR4  
Two-hybrid Homo sapiens
8 PLSCR1 5359
Two-hybrid Homo sapiens
9 IL16  
Two-hybrid Homo sapiens
10 TU3A  
Two-hybrid Homo sapiens
11 LINGO1 84894
Two-hybrid Homo sapiens
12 ZNF426  
Two-hybrid Homo sapiens
13 BAG6 7917
Two-hybrid Homo sapiens
14 SGTB  
Two-hybrid Homo sapiens
15 CCNK  
Two-hybrid Homo sapiens
16 TP53  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
17 ZNF638 27332
Two-hybrid Homo sapiens
18 RHPN1  
Two-hybrid Homo sapiens
19 RIBC2  
Two-hybrid Homo sapiens
20 GLRX3 10539
Two-hybrid Homo sapiens
21 COL8A1 1295
Two-hybrid Homo sapiens
22 SGTA 6449
Two-hybrid Homo sapiens
23 APEX2  
Two-hybrid Homo sapiens
24 UBQLN1 29979
Two-hybrid Homo sapiens
25 ZNF263  
Two-hybrid Homo sapiens
26 PEPP-2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
27 CATSPER1  
Two-hybrid Homo sapiens
28 CCND3  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which EFEMP2 is involved
PathwayEvidenceSource
Molecules associated with elastic fibres TAS Reactome





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