Gene description for TSEN15
Gene name TSEN15 tRNA splicing endonuclease subunit
Gene symbol TSEN15
Other names/aliases C1orf19
sen15
Species Homo sapiens
 Database cross references - TSEN15
ExoCarta ExoCarta_116461
Vesiclepedia VP_116461
Entrez Gene 116461
HGNC 16791
MIM 608756
UniProt Q8WW01  
 TSEN15 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TSEN15
Molecular Function
    nucleic acid binding GO:0003676 IEA
    protein binding GO:0005515 IPI
Biological Process
    tRNA splicing, via endonucleolytic cleavage and ligation GO:0006388 IEA
    mRNA processing GO:0006397 IEA
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    nucleolus GO:0005730 IEA
 Experiment description of studies that identified TSEN15 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TSEN15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AASDHPPT 60496
Affinity Capture-MS Homo sapiens
2 POLR2G 5436
Two-hybrid Homo sapiens
3 NBPF3  
Two-hybrid Homo sapiens
4 ENKD1  
Two-hybrid Homo sapiens
5 MINK1 50488
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 DECR2 26063
Affinity Capture-MS Homo sapiens
7 PLB1  
Two-hybrid Homo sapiens
8 USP7 7874
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TSSK2  
Two-hybrid Homo sapiens
10 LMO4  
Two-hybrid Homo sapiens
11 PAEP  
Affinity Capture-MS Homo sapiens
12 ARID5A  
Two-hybrid Homo sapiens
13 TULP4 56995
Affinity Capture-MS Homo sapiens
14 MEI4  
Two-hybrid Homo sapiens
15 LMNB2 84823
Affinity Capture-MS Homo sapiens
16 AES 166
Two-hybrid Homo sapiens
17 REL 5966
Two-hybrid Homo sapiens
18 MFI2 4241
Affinity Capture-MS Homo sapiens
19 INCA1  
Two-hybrid Homo sapiens
20 USP54 159195
Two-hybrid Homo sapiens
21 AGMAT  
Affinity Capture-MS Homo sapiens
22 TSEN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 AIF1L 83543
Two-hybrid Homo sapiens
24 PHOSPHO2  
Two-hybrid Homo sapiens
25 DDIT4L  
Two-hybrid Homo sapiens
26 PRR3  
Affinity Capture-MS Homo sapiens
27 CCDC33 80125
Two-hybrid Homo sapiens
28 LAMTOR5 10542
Affinity Capture-MS Homo sapiens
29 IKZF3  
Two-hybrid Homo sapiens
30 CLP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 LRIF1  
Two-hybrid Homo sapiens
32 ZMAT2  
Two-hybrid Homo sapiens
33 TSEN34 79042
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 ASB12  
Two-hybrid Homo sapiens
35 LMO2  
Two-hybrid Homo sapiens
36 PBX4  
Two-hybrid Homo sapiens
37 NRBP1 29959
Affinity Capture-MS Homo sapiens
38 MSMB  
Affinity Capture-MS Homo sapiens
39 POU6F2  
Two-hybrid Homo sapiens
40 ZNF620  
Two-hybrid Homo sapiens
41 ZNF554  
Two-hybrid Homo sapiens
42 FAM208B 54906
Two-hybrid Homo sapiens
43 GORASP2 26003
Two-hybrid Homo sapiens
44 TSEN54  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 ZNF215  
Affinity Capture-MS Homo sapiens
46 RANGRF  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 KRAS 3845
Negative Genetic Homo sapiens
48 MIPOL1  
Two-hybrid Homo sapiens
49 HSF2BP  
Two-hybrid Homo sapiens
50 VCPIP1 80124
Affinity Capture-MS Homo sapiens
51 ENTHD2  
Two-hybrid Homo sapiens
52 NAGPA 51172
Affinity Capture-MS Homo sapiens
53 RAB15 376267
Affinity Capture-MS Homo sapiens
54 EXOSC4 54512
Two-hybrid Homo sapiens
55 KLHL14 57565
Affinity Capture-MS Homo sapiens
56 Clp1  
Affinity Capture-MS Mus musculus
57 PSMC3 5702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TSEN15 is involved
PathwayEvidenceSource
Metabolism of RNA TAS Reactome
tRNA processing TAS Reactome
tRNA processing in the nucleus TAS Reactome





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