Gene description for TAF9
Gene name TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
Gene symbol TAF9
Other names/aliases MGC:5067
STAF31/32
TAF2G
TAFII-31
TAFII-32
TAFII31
TAFII32
TAFIID32
Species Homo sapiens
 Database cross references - TAF9
ExoCarta ExoCarta_6880
Vesiclepedia VP_6880
Entrez Gene 6880
HGNC 11542
MIM 600822
UniProt Q16594  
 TAF9 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for TAF9
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    p53 binding GO:0002039 IPI
    DNA binding GO:0003677 IDA
    transcription coactivator activity GO:0003713 IBA
    transcription coactivator activity GO:0003713 IDA
    transcription coactivator activity GO:0003713 IMP
    histone acetyltransferase activity GO:0004402 IDA
    protein binding GO:0005515 IPI
    RNA polymerase II general transcription initiation factor activity GO:0016251 IBA
    RNA polymerase II general transcription initiation factor activity GO:0016251 IC
    protein heterodimerization activity GO:0046982 IEA
    ATPase binding GO:0051117 IPI
    C2H2 zinc finger domain binding GO:0070742 IPI
    DNA-binding transcription factor binding GO:0140297 IPI
Biological Process
    box C/D snoRNP assembly GO:0000492 IDA
    regulation of DNA repair GO:0006282 NAS
    chromatin remodeling GO:0006338 IEA
    regulation of DNA-templated transcription GO:0006355 NAS
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    DNA damage response GO:0006974 IC
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435 IDA
    mRNA transcription by RNA polymerase II GO:0042789 IDA
    negative regulation of apoptotic process GO:0043066 IMP
    regulation of RNA splicing GO:0043484 NAS
    positive regulation of DNA-templated transcription GO:0045893 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    protein stabilization GO:0050821 IDA
    RNA polymerase II preinitiation complex assembly GO:0051123 IBA
    RNA polymerase II preinitiation complex assembly GO:0051123 IPI
    RNA polymerase II preinitiation complex assembly GO:0051123 ISS
    positive regulation of transcription initiation by RNA polymerase II GO:0060261 IDA
    positive regulation of response to cytokine stimulus GO:0060760 IMP
    response to interleukin-1 GO:0070555 IMP
    response to L-glutamate GO:1902065 IEA
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 IC
Subcellular Localization
    SAGA complex GO:0000124 IBA
    SAGA complex GO:0000124 IDA
    SAGA complex GO:0000124 NAS
    nucleus GO:0005634 EXP
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    transcription factor TFIID complex GO:0005669 IBA
    transcription factor TFIID complex GO:0005669 IDA
    transcription factor TFIID complex GO:0005669 IPI
    transcription factor TFIID complex GO:0005669 ISS
    transcription factor TFTC complex GO:0033276 IBA
    transcription factor TFTC complex GO:0033276 IDA
    transcription factor TFTC complex GO:0033276 NAS
    pre-snoRNP complex GO:0070761 IDA
    MLL1 complex GO:0071339 IDA
 Experiment description of studies that identified TAF9 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for TAF9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TADA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
2 ANK2 287
Reconstituted Complex Homo sapiens
3 COIL  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
4 FEV  
Proximity Label-MS Homo sapiens
5 KIAA1107  
Affinity Capture-MS Homo sapiens
6 KPNA1 3836
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 TRRAP 8295
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
8 ATXN7L2  
Affinity Capture-MS Homo sapiens
9 TADA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
10 TAF1L  
Co-fractionation Homo sapiens
11 EN1  
Proximity Label-MS Homo sapiens
12 UBA1 7317
Two-hybrid Homo sapiens
13 DHX8 1659
Co-fractionation Homo sapiens
14 TAF3 83860
Affinity Capture-MS Homo sapiens
15 ZZZ3  
Affinity Capture-MS Homo sapiens
16 BRD2  
Affinity Capture-MS Homo sapiens
17 RNF138  
Two-hybrid Homo sapiens
18 TAF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
19 TAF8  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 APP 351
Reconstituted Complex Homo sapiens
21 TAF5  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
22 TRPC5  
Affinity Capture-MS Homo sapiens
23 RBM48  
Two-hybrid Homo sapiens
24 RUVBL1 8607
Reconstituted Complex Homo sapiens
25 NCOR1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
26 KLF8  
Proximity Label-MS Homo sapiens
27 NDRG1 10397
Two-hybrid Homo sapiens
28 NUFIP1  
Reconstituted Complex Homo sapiens
29 FBXW7  
Affinity Capture-MS Homo sapiens
30 KLF6  
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
31 FBL 2091
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
32 TFEB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 CHD2 1106
Co-fractionation Homo sapiens
34 USP27X  
Affinity Capture-MS Homo sapiens
35 YEATS2  
Affinity Capture-MS Homo sapiens
36 CD14 929
Affinity Capture-MS Homo sapiens
37 MECP2 4204
Affinity Capture-MS Homo sapiens
38 SMARCA2 6595
Affinity Capture-Western Homo sapiens
39 EEF1A1 1915
Two-hybrid Homo sapiens
40 TAF5L  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
41 USP22 23326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 EDC4 23644
Affinity Capture-MS Homo sapiens
43 AURKA 6790
Affinity Capture-MS Homo sapiens
44 MYB  
Proximity Label-MS Homo sapiens
45 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
46 FBLN1 2192
Two-hybrid Homo sapiens
47 TAF10 6881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
48 SPATA25  
Affinity Capture-MS Homo sapiens
49 SUPT7L  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
50 TAF9B  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
51 DRAP1 10589
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
52 TAF12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
53 ALDH3B1 221
Affinity Capture-MS Homo sapiens
54 SUPT3H  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
55 RPA4  
Proximity Label-MS Homo sapiens
56 CCDC101  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ENY2 56943
Affinity Capture-MS Homo sapiens
58 MYCL  
Affinity Capture-MS Homo sapiens
59 CEBPA  
Proximity Label-MS Homo sapiens
60 TAF6L 10629
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
61 TAF13  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
62 TAF7L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 TAF7  
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
64 EGLN3  
Affinity Capture-MS Homo sapiens
65 MBIP  
Affinity Capture-MS Homo sapiens
66 IKZF3  
Affinity Capture-MS Homo sapiens
67 GALNT6 11226
Two-hybrid Homo sapiens
68 FEZ1  
Reconstituted Complex Homo sapiens
69 CSRP2BP  
Affinity Capture-MS Homo sapiens
70 YY1 7528
Proximity Label-MS Homo sapiens
71 CIITA  
Reconstituted Complex Homo sapiens
72 FOXL1  
Affinity Capture-MS Homo sapiens
73 YIPF5 81555
Affinity Capture-MS Homo sapiens
74 IKZF1  
Affinity Capture-MS Homo sapiens
75 ELP2 55250
Co-fractionation Homo sapiens
76 HIST3H3 8290
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
77 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
78 MAGEC2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
79 TBP  
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
80 HNF4A  
Proximity Label-MS Homo sapiens
81 TADA2A  
Affinity Capture-MS Homo sapiens
82 MYC  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
83 RPA3 6119
Proximity Label-MS Homo sapiens
84 AHR 196
Reconstituted Complex Homo sapiens
85 RPS14 6208
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
86 SF3B3 23450
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
87 TBCA 6902
Reconstituted Complex Homo sapiens
88 TADA2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 NFATC2  
Reconstituted Complex Homo sapiens
90 BRD3 8019
Affinity Capture-MS Homo sapiens
91 C9orf72  
Affinity Capture-MS Homo sapiens
92 TAF4 6874
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
93 LAMTOR5 10542
Two-hybrid Homo sapiens
94 RELA 5970
Reconstituted Complex Homo sapiens
95 TAF6 6878
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Co-fractionation Homo sapiens
96 SF3B5 83443
Affinity Capture-MS Homo sapiens
97 LLGL2 3993
Affinity Capture-MS Homo sapiens
98 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
99 KAT2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
100 SUPT20H 55578
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 TP53 7157
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
102 SIN3A  
Affinity Capture-Western Homo sapiens
103 LDLRAD1  
Affinity Capture-MS Homo sapiens
104 RUVBL2 10856
Reconstituted Complex Homo sapiens
105 KAT2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 ATXN7  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
107 KLF3  
Proximity Label-MS Homo sapiens
108 KPNA6 23633
Two-hybrid Homo sapiens
109 NCOA2 10499
Reconstituted Complex Homo sapiens
110 FKBP4 2288
Co-fractionation Homo sapiens
111 TAF2  
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
112 MAGEA9  
Affinity Capture-MS Homo sapiens
113 DDX58 23586
Affinity Capture-RNA Homo sapiens
114 GTF2B 2959
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
115 ELF3 1999
Reconstituted Complex Homo sapiens
116 KRR1 11103
Affinity Capture-MS Homo sapiens
117 RPS24 6229
Reconstituted Complex Homo sapiens
118 FOXS1  
Affinity Capture-MS Homo sapiens
119 HSF1  
Reconstituted Complex Homo sapiens
120 ZCCHC10  
Affinity Capture-MS Homo sapiens
121 CEBPB  
Reconstituted Complex Homo sapiens
122 ATXN7L3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 SP7  
Proximity Label-MS Homo sapiens
124 NR1D2  
Reconstituted Complex Homo sapiens
125 DR1  
Affinity Capture-MS Homo sapiens
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