Gene description for PDP1
Gene name pyruvate dehyrogenase phosphatase catalytic subunit 1
Gene symbol PDP1
Other names/aliases PDH
PDP
PDPC
PPM2C
Species Homo sapiens
 Database cross references - PDP1
ExoCarta ExoCarta_54704
Vesiclepedia VP_54704
Entrez Gene 54704
HGNC 9279
MIM 605993
UniProt Q9P0J1  
 PDP1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PDP1
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 IDA
    [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity GO:0004741 IBA
    [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity GO:0004741 IDA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    signal transduction GO:0007165 IBA
    peptidyl-threonine dephosphorylation GO:0035970 IDA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 NAS
    mitochondrial matrix GO:0005759 TAS
    pyruvate dehydrogenase (lipoamide) phosphatase complex GO:0045253 NAS
 Experiment description of studies that identified PDP1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PDP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MPST 4357
Co-fractionation Homo sapiens
2 C1orf198 84886
Co-fractionation Homo sapiens
3 PRKCD 5580
Affinity Capture-Western Homo sapiens
4 SPRED2 200734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 DDAH1 23576
Co-fractionation Homo sapiens
6 CLEC18A  
Affinity Capture-MS Homo sapiens
7 CMPK1 51727
Co-fractionation Homo sapiens
8 MTMR14 64419
Affinity Capture-MS Homo sapiens
9 MRPL37 51253
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ARCN1 372
Co-fractionation Homo sapiens
11 NENF 29937
Co-fractionation Homo sapiens
12 PARK7 11315
Co-fractionation Homo sapiens
13 PCGF2 7703
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 GRHPR 9380
Co-fractionation Homo sapiens
15 CBFA2T2  
Two-hybrid Homo sapiens
16 PLEKHG5 57449
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PMPCA 23203
Affinity Capture-MS Homo sapiens
18 RAB40C 57799
Affinity Capture-MS Homo sapiens
19 HARS2 23438
Affinity Capture-MS Homo sapiens
20 HINT2 84681
Co-fractionation Homo sapiens
21 PGLS 25796
Co-fractionation Homo sapiens
22 C1QC 714
Affinity Capture-MS Homo sapiens
23 DLL3  
Affinity Capture-MS Homo sapiens
24 IGFL3  
Affinity Capture-MS Homo sapiens
25 TRMT1 55621
Affinity Capture-MS Homo sapiens
26 NDUFAB1 4706
Co-fractionation Homo sapiens
27 PNOC  
Affinity Capture-MS Homo sapiens
28 PMPCB 9512
Affinity Capture-MS Homo sapiens
29 FGFR1 2260
Reconstituted Complex Homo sapiens
30 SOD1 6647
Co-fractionation Homo sapiens
31 FEN1 2237
Co-fractionation Homo sapiens
32 TPT1 7178
Co-fractionation Homo sapiens
33 WRN 7486
Affinity Capture-MS Homo sapiens
34 ALAS1  
Affinity Capture-MS Homo sapiens
35 CHST7  
Affinity Capture-MS Homo sapiens
36 SDHA 6389
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 BMP4 652
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 PARK2  
Affinity Capture-MS Homo sapiens
39 SAMD4A 23034
Affinity Capture-MS Homo sapiens
40 PLD2 5338
Affinity Capture-MS Homo sapiens
41 KRTAP6-2  
Two-hybrid Homo sapiens
42 OGT 8473
Reconstituted Complex Homo sapiens
43 FAM24B  
Affinity Capture-MS Homo sapiens
44 MEOX2  
Two-hybrid Homo sapiens
45 PPA2 27068
Co-fractionation Homo sapiens
46 ENO1 2023
Co-fractionation Homo sapiens
47 DBT 1629
Affinity Capture-MS Homo sapiens
48 RAB11FIP5 26056
Co-fractionation Homo sapiens
49 LATS2 26524
Affinity Capture-MS Homo sapiens
50 CLIC4 25932
Co-fractionation Homo sapiens
51 UCHL1 7345
Co-fractionation Homo sapiens
52 DDAH2 23564
Co-fractionation Homo sapiens
53 ACAT1 38
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
54 AK2 204
Co-fractionation Homo sapiens
55 NDUFA9 4704
Affinity Capture-MS Homo sapiens
56 IL25  
Affinity Capture-MS Homo sapiens
57 GCSH 2653
Co-fractionation Homo sapiens
58 NR3C1 2908
Affinity Capture-Western Homo sapiens
59 EGFR 1956
Reconstituted Complex Homo sapiens
60 TOP3A  
Affinity Capture-MS Homo sapiens
61 HDHD3 81932
Co-fractionation Homo sapiens
62 SPTBN1 6711
Affinity Capture-MS Homo sapiens
63 SAMD4B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 NOS2  
Co-fractionation Homo sapiens
65 NLRP1  
Affinity Capture-MS Homo sapiens
66 LACTB2 51110
Co-fractionation Homo sapiens
67 TFAP2D  
Affinity Capture-MS Homo sapiens
68 PDPR 55066
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 WDR44 54521
Affinity Capture-MS Homo sapiens
70 HINT1 3094
Co-fractionation Homo sapiens
71 SIRT3  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
72 CORO1C 23603
Affinity Capture-MS Homo sapiens
73 PKP3 11187
Affinity Capture-MS Homo sapiens
74 HIF1A 3091
Affinity Capture-MS Homo sapiens
75 CS 1431
Proximity Label-MS Homo sapiens
76 SPTAN1 6709
Affinity Capture-MS Homo sapiens
77 CLIC1 1192
Co-fractionation Homo sapiens
78 SNUPN 10073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 LARS2 23395
Affinity Capture-MS Homo sapiens
80 INCA1  
Two-hybrid Homo sapiens
81 PDHA1 5160
Proximity Label-MS Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
82 C21orf33  
Co-fractionation Homo sapiens
83 ERCC3  
Co-fractionation Homo sapiens
84 IDH2 3418
Co-fractionation Homo sapiens
85 ADIPOQ 9370
Affinity Capture-MS Homo sapiens
86 AARS2  
Proximity Label-MS Homo sapiens
87 PRDX6 9588
Co-fractionation Homo sapiens
88 PRDX1 5052
Co-fractionation Homo sapiens
89 ACO2 50
Co-fractionation Homo sapiens
90 LOX 4015
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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