Gene description for SDC2
Gene name syndecan 2
Gene symbol SDC2
Other names/aliases CD362
Species Homo sapiens
 Database cross references - SDC2
ExoCarta ExoCarta_6383
Entrez Gene 6383
HGNC 10659
MIM 142460
UniProt P34741  
 SDC2 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for SDC2
Molecular Function
    PDZ domain binding GO:0030165 IPI
    protein binding GO:0005515 IPI
Biological Process
    response to hypoxia GO:0001666 IEA
    chondroitin sulfate metabolic process GO:0030204 TAS
    ephrin receptor signaling pathway GO:0048013 TAS
    glycosaminoglycan biosynthetic process GO:0006024 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    regulation of dendrite morphogenesis GO:0048814 ISS
    extracellular matrix organization GO:0030198 TAS
    response to caffeine GO:0031000 IEA
    cell migration GO:0016477 IBA
    glycosaminoglycan catabolic process GO:0006027 TAS
    biological_process GO:0008150 ND
    small molecule metabolic process GO:0044281 TAS
    wound healing GO:0042060 IEA
    phototransduction, visible light GO:0007603 TAS
    carbohydrate metabolic process GO:0005975 TAS
    retinoid metabolic process GO:0001523 TAS
    dendrite morphogenesis GO:0048813 IBA
    axon guidance GO:0007411 TAS
Subcellular Localization
    lysosomal lumen GO:0043202 TAS
    Golgi lumen GO:0005796 TAS
    synapse GO:0045202 IEA
    neuronal cell body GO:0043025 IEA
    integral component of membrane GO:0016021 IEA
    cell surface GO:0009986 IBA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified SDC2 in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for SDC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITPR1  
Affinity Capture-Western Homo sapiens
2 FN1 2335
Invivo Homo sapiens
Invitro Homo sapiens
3 HGF 3082
Reconstituted Complex Homo sapiens
4 EZR 7430
Invivo Homo sapiens
Invitro Homo sapiens
5 PF4  
Invitro Homo sapiens
6 EPB41L1 2036
Affinity Capture-Western Homo sapiens
7 REG3A  
Invitro Homo sapiens
8 SDCBP 6386
Reconstituted Complex Homo sapiens
9 CSF2 1437
Reconstituted Complex Homo sapiens
10 KAL1  
Invivo Homo sapiens
11 LAMA3 3909
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 CSF2RA  
Affinity Capture-Western Homo sapiens
13 SERPINC1 462
Invivo Homo sapiens
14 FGF2 2247
Co-purification Homo sapiens
15 CASK 8573
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml

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