Gene description for SORT1
Gene name sortilin 1
Gene symbol SORT1
Other names/aliases Gp95
LDLCQ6
NT3
Species Homo sapiens
 Database cross references - SORT1
ExoCarta ExoCarta_6272
Vesiclepedia VP_6272
Entrez Gene 6272
HGNC 11186
MIM 602458
UniProt Q99523  
 SORT1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 19837982    
Melanoma cells 25950383    
Mesenchymal stem cells Unpublished / Not applicable
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SORT1
Molecular Function
    protein binding GO:0005515 IPI
    nerve growth factor receptor activity GO:0010465 IDA
    enzyme binding GO:0019899 IPI
    neurotensin receptor activity, non-G protein-coupled GO:0030379 IDA
    nerve growth factor binding GO:0048406 IPI
    retromer complex binding GO:1905394 IDA
Biological Process
    ossification GO:0001503 IEA
    protein targeting to lysosome GO:0006622 IEA
    Golgi to endosome transport GO:0006895 IBA
    Golgi to endosome transport GO:0006895 IDA
    endocytosis GO:0006897 IBA
    endocytosis GO:0006897 IDA
    G protein-coupled receptor signaling pathway GO:0007186 IMP
    neuropeptide signaling pathway GO:0007218 IDA
    endosome to lysosome transport GO:0008333 IDA
    extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 IDA
    regulation of gene expression GO:0010468 IMP
    myotube differentiation GO:0014902 IMP
    vesicle organization GO:0016050 IBA
    vesicle organization GO:0016050 IDA
    endosome transport via multivesicular body sorting pathway GO:0032509 IDA
    response to insulin GO:0032868 IMP
    nerve growth factor signaling pathway GO:0038180 IEA
    negative regulation of fat cell differentiation GO:0045599 IEA
    D-glucose import GO:0046323 IMP
    neurotrophin TRK receptor signaling pathway GO:0048011 IMP
    plasma membrane to endosome transport GO:0048227 IDA
    negative regulation of lipoprotein lipase activity GO:0051005 IDA
    Golgi to lysosome transport GO:0090160 IDA
    maintenance of synapse structure GO:0099558 IEA
Subcellular Localization
    lysosome GO:0005764 IDA
    lysosomal membrane GO:0005765 IEA
    early endosome GO:0005769 IDA
    endoplasmic reticulum membrane GO:0005789 IEA
    Golgi apparatus GO:0005794 IBA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 NAS
    clathrin-coated pit GO:0005905 IDA
    cell surface GO:0009986 IDA
    endosome membrane GO:0010008 IDA
    membrane GO:0016020 IBA
    membrane GO:0016020 IDA
    clathrin-coated vesicle GO:0030136 IDA
    trans-Golgi network transport vesicle GO:0030140 IEA
    cytoplasmic vesicle GO:0031410 IDA
    nuclear membrane GO:0031965 IEA
    Golgi cisterna membrane GO:0032580 IEA
    perinuclear region of cytoplasm GO:0048471 IDA
    cerebellar climbing fiber to Purkinje cell synapse GO:0150053 IEA
 Experiment description of studies that identified SORT1 in exosomes
1
Experiment ID 21
MISEV standards
EM|IEM
Biophysical techniques
Alix|TSG101|HSP70|CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors "Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson"
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 257
MISEV standards
EM
Biophysical techniques
TSG101|FLOT1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
4
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 231
MISEV standards
Biophysical techniques
Alix|CD63|CD9
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 232
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 233
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 834
MISEV standards
EM
Biophysical techniques
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 835
MISEV standards
EM
Biophysical techniques
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SORT1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MORC2  
Affinity Capture-MS Homo sapiens
2 UGGT2 55757
Affinity Capture-MS Homo sapiens
3 SGCA  
Affinity Capture-MS Homo sapiens
4 UTP15 84135
Affinity Capture-MS Homo sapiens
5 XIAP  
Affinity Capture-MS Homo sapiens
6 SORL1 6653
Reconstituted Complex Homo sapiens
7 CD8B 926
Affinity Capture-MS Homo sapiens
8 HLA-E 3133
Affinity Capture-MS Homo sapiens
9 SCYL1 57410
Affinity Capture-MS Homo sapiens
10 ACAA1 30
Affinity Capture-MS Homo sapiens
11 CSNK1G2 1455
Affinity Capture-MS Homo sapiens
12 DNAJA4 55466
Affinity Capture-MS Homo sapiens
13 URB1 9875
Affinity Capture-MS Homo sapiens
14 FBXL19  
Affinity Capture-MS Homo sapiens
15 NUDCD3 23386
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
16 NDUFB5 4711
Affinity Capture-MS Homo sapiens
17 MED13L 23389
Affinity Capture-MS Homo sapiens
18 C9orf78 51759
Affinity Capture-MS Homo sapiens
19 URB2  
Affinity Capture-MS Homo sapiens
20 TBC1D8  
Affinity Capture-MS Homo sapiens
21 RET 5979
Affinity Capture-MS Homo sapiens
22 SRSF2 6427
Affinity Capture-MS Homo sapiens
23 GGA2 23062
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
24 COPA 1314
Affinity Capture-MS Homo sapiens
25 PDE12 201626
Affinity Capture-MS Homo sapiens
26 SLC22A9  
Affinity Capture-MS Homo sapiens
27 PI4KA 5297
Affinity Capture-MS Homo sapiens
28 UAP1 6675
Affinity Capture-MS Homo sapiens
29 TRIOBP 11078
Affinity Capture-MS Homo sapiens
30 HP 3240
Affinity Capture-MS Homo sapiens
31 B4GALT4 8702
Affinity Capture-MS Homo sapiens
32 PALMD  
Affinity Capture-MS Homo sapiens
33 MYH6 4624
Affinity Capture-MS Homo sapiens
34 TUBB 203068
Affinity Capture-MS Homo sapiens
35 APBB2  
Affinity Capture-MS Homo sapiens
36 TLN1 7094
Affinity Capture-MS Homo sapiens
37 HEY1  
Affinity Capture-MS Homo sapiens
38 CLEC2B  
Affinity Capture-MS Homo sapiens
39 SSR1 6745
Affinity Capture-MS Homo sapiens
40 GGA1 26088
Two-hybrid Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
41 DDX51  
Affinity Capture-MS Homo sapiens
42 PEAK1 79834
Affinity Capture-MS Homo sapiens
43 UFSP2 55325
Affinity Capture-MS Homo sapiens
44 WHSC1 7468
Affinity Capture-MS Homo sapiens
45 PRCC  
Affinity Capture-MS Homo sapiens
46 HSD17B4 3295
Affinity Capture-MS Homo sapiens
47 MPHOSPH6 10200
Affinity Capture-MS Homo sapiens
48 OASL 8638
Affinity Capture-MS Homo sapiens
49 PLCB3 5331
Affinity Capture-MS Homo sapiens
50 FAF2 23197
Affinity Capture-MS Homo sapiens
51 ICE2  
Affinity Capture-MS Homo sapiens
52 HELT  
Affinity Capture-MS Homo sapiens
53 COBLL1 22837
Affinity Capture-MS Homo sapiens
54 TAZ  
Affinity Capture-MS Homo sapiens
55 TCOF1 6949
Affinity Capture-MS Homo sapiens
56 CD70 970
Affinity Capture-MS Homo sapiens
57 FANCM 57697
Affinity Capture-MS Homo sapiens
58 PTPRN2  
Affinity Capture-MS Homo sapiens
59 XRCC2  
Affinity Capture-MS Homo sapiens
60 USP11 8237
Affinity Capture-MS Homo sapiens
61 KLHDC2  
Affinity Capture-MS Homo sapiens
62 SBF2 81846
Affinity Capture-MS Homo sapiens
63 KLC1 3831
Affinity Capture-MS Homo sapiens
64 GPR128  
Two-hybrid Homo sapiens
65 CENPV 201161
Affinity Capture-MS Homo sapiens
66 GTF2IRD1  
Affinity Capture-MS Homo sapiens
67 NHS 4810
Affinity Capture-MS Homo sapiens
68 MUS81  
Affinity Capture-MS Homo sapiens
69 TEC 7006
Affinity Capture-MS Homo sapiens
70 NOP2 4839
Affinity Capture-MS Homo sapiens
71 CSPG4 1464
Affinity Capture-MS Homo sapiens
72 TUBA1C 84790
Affinity Capture-MS Homo sapiens
73 NTRK1 4914
Affinity Capture-MS Homo sapiens
74 LEMD2 221496
Affinity Capture-MS Homo sapiens
75 SIRPD  
Affinity Capture-MS Homo sapiens
76 KRT75 9119
Affinity Capture-MS Homo sapiens
77 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
78 MIA3 375056
Affinity Capture-MS Homo sapiens
79 DICER1  
Affinity Capture-MS Homo sapiens
80 WNT10A  
Affinity Capture-MS Homo sapiens
81 RAB11FIP5 26056
Affinity Capture-MS Homo sapiens
82 RRP1B 23076
Affinity Capture-MS Homo sapiens
83 LMTK2 22853
Affinity Capture-MS Homo sapiens
84 ICAM5 7087
Affinity Capture-MS Homo sapiens
85 CACNG4  
Affinity Capture-MS Homo sapiens
86 TXNDC11 51061
Affinity Capture-MS Homo sapiens
87 STAM 8027
Affinity Capture-Western Homo sapiens
88 LY86  
Affinity Capture-MS Homo sapiens
89 UPK2 7379
Affinity Capture-MS Homo sapiens
90 EME1  
Affinity Capture-MS Homo sapiens
91 MRM1  
Affinity Capture-MS Homo sapiens
92 S1PR1 1901
Affinity Capture-MS Homo sapiens
93 SLC25A25  
Affinity Capture-MS Homo sapiens
94 ARHGAP32  
Affinity Capture-MS Homo sapiens
95 GOLGA3 2802
Affinity Capture-MS Homo sapiens
96 KIAA1191  
Affinity Capture-MS Homo sapiens
97 CUL3 8452
Affinity Capture-MS Homo sapiens
98 CANX 821
Affinity Capture-MS Homo sapiens
99 ZNF768 79724
Affinity Capture-MS Homo sapiens
100 MRPL24  
Affinity Capture-MS Homo sapiens
101 USP15 9958
Affinity Capture-MS Homo sapiens
102 YBX1 4904
Affinity Capture-MS Homo sapiens
103 SORCS1  
Reconstituted Complex Homo sapiens
104 DDX60 55601
Affinity Capture-MS Homo sapiens
105 ASS1 445
Affinity Capture-MS Homo sapiens
106 PAPD5 64282
Affinity Capture-MS Homo sapiens
107 AQP3  
Affinity Capture-MS Homo sapiens
108 UACA 55075
Affinity Capture-MS Homo sapiens
109 LAMTOR5 10542
Affinity Capture-MS Homo sapiens
110 SSH3 54961
Affinity Capture-MS Homo sapiens
111 TCIRG1 10312
Affinity Capture-MS Homo sapiens
112 CD27  
Affinity Capture-MS Homo sapiens
113 CDK2 1017
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 DIS3 22894
Affinity Capture-MS Homo sapiens
115 MAP3K4 4216
Affinity Capture-MS Homo sapiens
116 BLMH 642
Affinity Capture-MS Homo sapiens
117 MARCH4  
Affinity Capture-MS Homo sapiens
118 FNDC3A 22862
Affinity Capture-MS Homo sapiens
119 EVI2A  
Affinity Capture-MS Homo sapiens
120 SIRT5 23408
Affinity Capture-MS Homo sapiens
121 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
122 RBM28 55131
Affinity Capture-MS Homo sapiens
123 EIF2B1 1967
Affinity Capture-MS Homo sapiens
124 NOL6 65083
Affinity Capture-MS Homo sapiens
125 GBAP1  
Affinity Capture-MS Homo sapiens
126 IRF3 3661
Affinity Capture-MS Homo sapiens
127 MARCH6  
Affinity Capture-MS Homo sapiens
128 BAIAP2L1 55971
Affinity Capture-MS Homo sapiens
129 BAD  
Affinity Capture-MS Homo sapiens
130 GGA3 23163
Affinity Capture-Western Homo sapiens
131 SH3PXD2B 285590
Affinity Capture-MS Homo sapiens
132 TMEM9 252839
Affinity Capture-MS Homo sapiens
133 GPBP1  
Affinity Capture-MS Homo sapiens
134 C2orf69  
Affinity Capture-MS Homo sapiens
135 APTX  
Affinity Capture-MS Homo sapiens
136 NGF  
Reconstituted Complex Homo sapiens
137 FOXRED2  
Affinity Capture-MS Homo sapiens
138 USP1 7398
Affinity Capture-MS Homo sapiens
139 SPTBN2 6712
Affinity Capture-MS Homo sapiens
140 BACE1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
141 LSM14A 26065
Affinity Capture-MS Homo sapiens
142 ABCA7 10347
Affinity Capture-MS Homo sapiens
143 PARP9 83666
Affinity Capture-MS Homo sapiens
144 YARS 8565
Affinity Capture-MS Homo sapiens
145 TSEN2  
Affinity Capture-MS Homo sapiens
146 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
147 USP32 84669
Affinity Capture-MS Homo sapiens
148 BDNF 627
Two-hybrid Homo sapiens
149 MYH1  
Affinity Capture-MS Homo sapiens
150 CDK1 983
Affinity Capture-MS Homo sapiens
151 BRIX1 55299
Affinity Capture-MS Homo sapiens
152 WWP2 11060
Affinity Capture-MS Homo sapiens
153 LRPAP1 4043
Reconstituted Complex Homo sapiens
154 BRICD5  
Two-hybrid Homo sapiens
155 UPF1 5976
Affinity Capture-MS Homo sapiens
156 RAB13 5872
Affinity Capture-MS Homo sapiens
157 CLTA 1211
Affinity Capture-MS Homo sapiens
158 BIN3 55909
Affinity Capture-MS Homo sapiens
159 C2CD5 9847
Affinity Capture-MS Homo sapiens
160 FOXR1  
Affinity Capture-MS Homo sapiens
161 CDRT4  
Affinity Capture-MS Homo sapiens
162 MRPL55  
Affinity Capture-MS Homo sapiens
163 PHC2  
Affinity Capture-MS Homo sapiens
164 SLC1A1 6505
Affinity Capture-MS Homo sapiens
165 NSMCE2  
Affinity Capture-MS Homo sapiens
166 CNIH3  
Two-hybrid Homo sapiens
167 IPO9 55705
Affinity Capture-MS Homo sapiens
168 HLA-C 3107
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here