Gene description for ZSWIM8
Gene name zinc finger, SWIM-type containing 8
Gene symbol ZSWIM8
Other names/aliases KIAA0913
Species Homo sapiens
 Database cross references - ZSWIM8
ExoCarta ExoCarta_23053
Vesiclepedia VP_23053
Entrez Gene 23053
HGNC 23528
UniProt A7E2V4  
 ZSWIM8 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for ZSWIM8
Molecular Function
    zinc ion binding GO:0008270 IEA
    ubiquitin-like ligase-substrate adaptor activity GO:1990756 IDA
Biological Process
    protein quality control for misfolded or incompletely synthesized proteins GO:0006515 IDA
    protein ubiquitination GO:0016567 IDA
    protein ubiquitination GO:0016567 IEA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA
    target-directed miRNA degradation GO:0140958 IMP
    positive regulation of miRNA catabolic process GO:2000627 IDA
Subcellular Localization
    cytosol GO:0005829 ISS
    Cul2-RING ubiquitin ligase complex GO:0031462 IBA
    Cul3-RING ubiquitin ligase complex GO:0031463 IDA
 Experiment description of studies that identified ZSWIM8 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ZSWIM8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSG11  
Affinity Capture-MS Homo sapiens
2 ATXN1 6310
Two-hybrid Homo sapiens
3 C2CD4B  
Affinity Capture-MS Homo sapiens
4 ASB3 51130
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 FGF11  
Affinity Capture-MS Homo sapiens
6 MRPL4 51073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 C9orf163  
Affinity Capture-MS Homo sapiens
8 FGF14  
Affinity Capture-MS Homo sapiens
9 XPO1 7514
Affinity Capture-MS Homo sapiens
10 JPH4 84502
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 TSPYL6  
Affinity Capture-MS Homo sapiens
12 SIRT7  
Affinity Capture-MS Homo sapiens
13 ATXN1L  
Two-hybrid Homo sapiens
14 AURKA 6790
Affinity Capture-MS Homo sapiens
15 SULT1C4  
Affinity Capture-MS Homo sapiens
16 PRG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 RPL15 6138
Affinity Capture-MS Homo sapiens
19 PLBD1 79887
Affinity Capture-MS Homo sapiens
20 SOCS1  
Affinity Capture-MS Homo sapiens
21 DCLRE1C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 METTL21B  
Affinity Capture-MS Homo sapiens
23 B4GALT2  
Affinity Capture-MS Homo sapiens
24 ATN1  
Two-hybrid Homo sapiens
25 DUSP16  
Affinity Capture-MS Homo sapiens
26 PLD1 5337
Affinity Capture-MS Homo sapiens
27 APEX1 328
Affinity Capture-RNA Homo sapiens
28 AGO4  
Affinity Capture-MS Homo sapiens
29 C12orf74  
Affinity Capture-MS Homo sapiens
30 SP110  
Affinity Capture-MS Homo sapiens
31 ZUFSP 221302
Affinity Capture-MS Homo sapiens
32 CLASRP  
Affinity Capture-MS Homo sapiens
33 NTRK1 4914
Affinity Capture-MS Homo sapiens
34 D2HGDH 728294
Affinity Capture-MS Homo sapiens
35 OLFM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 NOS2  
Affinity Capture-MS Homo sapiens
37 TCEB2 6923
Affinity Capture-MS Homo sapiens
38 TXNIP 10628
Affinity Capture-MS Homo sapiens
39 CSNK1E 1454
Affinity Capture-MS Homo sapiens
40 TULP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 ARRDC2  
Affinity Capture-MS Homo sapiens
42 RPA2 6118
Proximity Label-MS Homo sapiens
43 RPA3 6119
Proximity Label-MS Homo sapiens
44 UBXN6 80700
Affinity Capture-MS Homo sapiens
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