Gene description for FGFRL1
Gene name fibroblast growth factor receptor-like 1
Gene symbol FGFRL1
Other names/aliases FGFR5
FHFR
Species Homo sapiens
 Database cross references - FGFRL1
ExoCarta ExoCarta_53834
Vesiclepedia VP_53834
Entrez Gene 53834
HGNC 3693
MIM 605830
UniProt Q8N441  
 FGFRL1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for FGFRL1
Molecular Function
    fibroblast growth factor receptor activity GO:0005007 IBA
    fibroblast growth factor receptor activity GO:0005007 IDA
    heparin binding GO:0008201 IDA
    heparin binding GO:0008201 IMP
    fibroblast growth factor binding GO:0017134 IBA
    identical protein binding GO:0042802 IPI
Biological Process
    skeletal system development GO:0001501 IEA
    heart valve morphogenesis GO:0003179 IEA
    negative regulation of cell population proliferation GO:0008285 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    ventricular septum morphogenesis GO:0060412 IEA
    diaphragm development GO:0060539 IEA
    cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 IMP
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    transport vesicle GO:0030133 IDA
    cell-cell contact zone GO:0044291 IDA
 Experiment description of studies that identified FGFRL1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Antibody array
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for FGFRL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HAL 3034
Affinity Capture-MS Homo sapiens
2 KIAA0232 9778
Affinity Capture-MS Homo sapiens
3 PPP1R15B  
Affinity Capture-MS Homo sapiens
4 PCDHGB1  
Affinity Capture-MS Homo sapiens
5 TMED10 10972
Affinity Capture-MS Homo sapiens
6 WDR5 11091
Co-localization Homo sapiens
7 TNFRSF1B  
Affinity Capture-MS Homo sapiens
8 KMT2A  
Co-localization Homo sapiens
9 ANKHD1-EIF4EBP3  
Affinity Capture-MS Homo sapiens
10 CLTCL1 8218
Affinity Capture-MS Homo sapiens
11 NRSN1  
Affinity Capture-MS Homo sapiens
12 LRP2 4036
Affinity Capture-MS Homo sapiens
13 TNFSF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 KRT35 3886
Affinity Capture-MS Homo sapiens
15 TMED5 50999
Affinity Capture-MS Homo sapiens
16 VPRBP 9730
Affinity Capture-MS Homo sapiens
17 CLK2 1196
Affinity Capture-MS Homo sapiens
18 ZZEF1 23140
Affinity Capture-MS Homo sapiens
19 CLEC4A  
Affinity Capture-MS Homo sapiens
20 ARRDC1 92714
Affinity Capture-MS Homo sapiens
21 ANKRD17 26057
Affinity Capture-MS Homo sapiens
22 KLRG2 346689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 DDX58 23586
Affinity Capture-RNA Homo sapiens
24 COPG1 22820
Affinity Capture-MS Homo sapiens
25 SDC2 6383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 NXF1 10482
Affinity Capture-RNA Homo sapiens
27 BACH1 571
Affinity Capture-MS Homo sapiens
28 SETD1A 9739
Affinity Capture-MS Homo sapiens
29 B3GAT1  
Proximity Label-MS Homo sapiens
30 TRIM44  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 HLA-DPA1  
Affinity Capture-MS Homo sapiens
32 CELSR2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 UBE2O 63893
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 EAF1  
Affinity Capture-MS Homo sapiens
35 TERF2  
Affinity Capture-MS Homo sapiens
36 TMED2 10959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 A2ML1 144568
Affinity Capture-MS Homo sapiens
38 CD44 960
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 AP3B1 8546
Affinity Capture-MS Homo sapiens
40 C16orf71  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 ANGEL1  
Affinity Capture-MS Homo sapiens
42 KPRP 448834
Affinity Capture-MS Homo sapiens
43 POF1B 79983
Affinity Capture-MS Homo sapiens
44 FLG2 388698
Affinity Capture-MS Homo sapiens
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