Gene description for CTSL
Gene name cathepsin L
Gene symbol CTSL
Other names/aliases CATL
CTSL1
MEP
Species Homo sapiens
 Database cross references - CTSL
ExoCarta ExoCarta_1514
Entrez Gene 1514
HGNC 2537
MIM 116880
UniProt P07711  
 CTSL identified in exosomes derived from the following tissue/cell type
Keratinocytes 19530224    
Keratinocytes 19530224    
 Gene ontology annotations for CTSL
Molecular Function
    protein binding GO:0005515 IPI
    collagen binding GO:0005518 IDA
    histone binding GO:0042393 IDA
    cysteine-type endopeptidase activity GO:0004197 IDA
    fibronectin binding GO:0001968 IPI
    cysteine-type peptidase activity GO:0008234 IDA
    proteoglycan binding GO:0043394 IPI
    serpin family protein binding GO:0097655 IPI
Biological Process
    proteolysis involved in cellular protein catabolic process GO:0051603 IDA
    antigen processing and presentation GO:0019882 TAS
    innate immune response GO:0045087 TAS
    extracellular matrix organization GO:0030198 TAS
    proteolysis GO:0006508 IDA
    macrophage apoptotic process GO:0071888 NAS
    cellular response to thyroid hormone stimulus GO:0097067 IEP
    toll-like receptor signaling pathway GO:0002224 TAS
    adaptive immune response GO:0002250 IEP
    collagen catabolic process GO:0030574 TAS
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 TAS
    extracellular matrix disassembly GO:0022617 TAS
Subcellular Localization
    extracellular space GO:0005615 IDA
    endolysosome lumen GO:0036021 TAS
    extracellular region GO:0005576 TAS
    lysosome GO:0005764 IDA
    lysosomal lumen GO:0043202 TAS
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 TAS
 Experiment description of studies that identified CTSL in exosomes
1
Experiment ID 189
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Differentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 190
ISEV standards
EM
EV Biophysical techniques
HSC70
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19530224    
Organism Homo sapiens
Experiment description Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes.
Authors Chavez-Muñoz C, Kilani RT, Ghahary A.
Journal name J Cell Physiol
Publication year 2009
Sample Keratinocytes
Sample name Keratinocytes - Undifferentiated
Isolation/purification methods Differential centrifugation
Filtration
Sucrose cushion
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CTSL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAPK1 5594
Invivo Homo sapiens
2 CST7  
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
3 SERPINB13 5275
Invitro Homo sapiens
4 RXRA  
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
5 SERPINB3 6317
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
6 CTSL 1514
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 CSTA 1475
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
8 KNG1 3827
Invitro Homo sapiens
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