Gene description for PNPLA1
Gene name patatin-like phospholipase domain containing 1
Gene symbol PNPLA1
Other names/aliases ARCI10
dJ50J22.1
Species Homo sapiens
 Database cross references - PNPLA1
ExoCarta ExoCarta_285848
Vesiclepedia VP_285848
Entrez Gene 285848
HGNC 21246
MIM 612121
UniProt Q8N8W4  
 PNPLA1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PNPLA1
Molecular Function
    triacylglycerol lipase activity GO:0004806 IBA
    acyltransferase activity, transferring groups other than amino-acyl groups GO:0016747 IMP
    structural constituent of skin epidermis GO:0030280 IC
    omega-hydroxyceramide transacylase activity GO:0106341 IDA
Biological Process
    triglyceride catabolic process GO:0019433 IBA
    ceramide biosynthetic process GO:0046513 IMP
    lipid homeostasis GO:0055088 IBA
    omega-hydroxyceramide biosynthetic process GO:0106342 IMP
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    lipid droplet GO:0005811 IBA
    membrane GO:0016020 IBA
 Experiment description of studies that identified PNPLA1 in exosomes
1
Experiment ID 211
MISEV standards
EM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
cytochrome c|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
MISEV standards
CEM
Biophysical techniques
TSG101|Alix|EpCAM|TFRC
Enriched markers
Cytochrome C|GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PNPLA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDCL 5082
Affinity Capture-MS Homo sapiens
2 ANKRD40 91369
Affinity Capture-MS Homo sapiens
3 TXNDC9 10190
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 UBR4 23352
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 METTL15  
Affinity Capture-MS Homo sapiens
6 CHMP3 51652
Affinity Capture-MS Homo sapiens
7 HBB 3043
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 BIRC6 57448
Affinity Capture-MS Homo sapiens
9 PARP14 54625
Affinity Capture-MS Homo sapiens
10 TMEM160 54958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 RNF123 63891
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PDCL3 79031
Affinity Capture-MS Homo sapiens
14 UBAC1 10422
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 NIF3L1 60491
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 CCT6B 10693
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CHMP1A 5119
Affinity Capture-MS Homo sapiens
18 UQCC1 55245
Affinity Capture-MS Homo sapiens
19 TCP1 6950
Affinity Capture-MS Homo sapiens
20 CCT2 10576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PNPLA1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here