Gene description for RBM3
Gene name RNA binding motif (RNP1, RRM) protein 3
Gene symbol RBM3
Other names/aliases IS1-RNPL
RNPL
Species Homo sapiens
 Database cross references - RBM3
ExoCarta ExoCarta_5935
Entrez Gene 5935
HGNC 9900
MIM 300027
UniProt P98179  
 RBM3 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Urine 15326289    
 Gene ontology annotations for RBM3
Molecular Function
    RNA binding GO:0003723 TAS
    ribosomal large subunit binding GO:0043023 IEA
    nucleotide binding GO:0000166 IEA
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
Biological Process
    regulation of translation GO:0006417 ISS
    translation GO:0006412 IEA
    RNA processing GO:0006396 TAS
    response to cold GO:0009409 IEA
    positive regulation of translation GO:0045727 ISS
    production of miRNAs involved in gene silencing by miRNA GO:0035196 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISS
    large ribosomal subunit GO:0015934 ISS
    dendrite GO:0030425 ISS
    nucleus GO:0005634 ISS
 Experiment description of studies that identified RBM3 in exosomes
1
Experiment ID 274
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
2
Experiment ID 13
ISEV standards
IEM
EV Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101
EV Cytosolic markers
CD9|AQP2|AQP1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors Pisitkun T, Shen RF, Knepper MA
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for RBM3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VCL 7414
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which RBM3 is involved
No pathways found





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