Gene description for S100A1
Gene name S100 calcium binding protein A1
Gene symbol S100A1
Other names/aliases S100
S100-alpha
S100A
Species Homo sapiens
 Database cross references - S100A1
ExoCarta ExoCarta_6271
Vesiclepedia VP_6271
Entrez Gene 6271
HGNC 10486
MIM 176940
UniProt P23297  
 S100A1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for S100A1
Molecular Function
    calcium ion binding GO:0005509 IBA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    S100 protein binding GO:0044548 IBA
    S100 protein binding GO:0044548 IPI
    calcium-dependent protein binding GO:0048306 IBA
    ATPase binding GO:0051117 IPI
Biological Process
    regulation of heart contraction GO:0008016 NAS
    substantia nigra development GO:0021762 HEP
    intracellular signal transduction GO:0035556 NAS
    positive regulation of nitric-oxide synthase activity GO:0051000 IDA
    positive regulation of sprouting angiogenesis GO:1903672 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    mitochondrion GO:0005739 IEA
    Golgi apparatus GO:0005794 IDA
    cytosol GO:0005829 IDA
    sarcoplasmic reticulum GO:0016529 IBA
    sarcoplasmic reticulum GO:0016529 IDA
    protein-containing complex GO:0032991 NAS
 Experiment description of studies that identified S100A1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for S100A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
2 PLB1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 S100P 6286
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 NIF3L1 60491
Two-hybrid Homo sapiens
5 TP53 7157
Reconstituted Complex Homo sapiens
6 GJA1 2697
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 NGFRAP1  
Two-hybrid Homo sapiens
8 S100A2 6273
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 PLEKHF2 79666
Two-hybrid Homo sapiens
10 DES 1674
Reconstituted Complex Homo sapiens
11 S100A3  
Two-hybrid Homo sapiens
12 FOPNL  
Reconstituted Complex Homo sapiens
13 ANXA6 309
Reconstituted Complex Homo sapiens
14 ATP2A2 488
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
15 RYR1 6261
Reconstituted Complex Homo sapiens
16 S100Z  
Two-hybrid Homo sapiens
17 PYGM 5837
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
18 S100A4 6275
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Two-hybrid Homo sapiens
19 S100B 6285
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
20 PGM1 5236
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 S100A1 6271
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-purification Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 MDM2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here