Gene description for TFF1
Gene name trefoil factor 1
Gene symbol TFF1
Other names/aliases BCEI
Species Homo sapiens
 Database cross references - TFF1
ExoCarta ExoCarta_7031
Entrez Gene 7031
HGNC 11755
MIM 113710
UniProt P04155  
 TFF1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for TFF1
Molecular Function
    growth factor activity GO:0008083 IEA
    protein binding GO:0005515 IPI
Biological Process
    digestion GO:0007586 NAS
    response to immobilization stress GO:0035902 IEA
    negative regulation of cell proliferation GO:0008285 IEA
    carbohydrate metabolic process GO:0005975 TAS
    maintenance of gastrointestinal epithelium GO:0030277 IEA
    response to peptide hormone GO:0043434 IEA
    cell differentiation GO:0030154 IEA
    response to iron ion GO:0010039 IEA
Subcellular Localization
    extracellular space GO:0005615 IEA
 Experiment description of studies that identified TFF1 in exosomes
Experiment ID 234
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TFF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TFF1 7031
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
2 UBQLN1 29979
Two-hybrid Homo sapiens
3 PTRF 284119
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which TFF1 is involved
No pathways found

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