Gene description for STRN3
Gene name striatin, calmodulin binding protein 3
Gene symbol STRN3
Other names/aliases SG2NA
Species Homo sapiens
 Database cross references - STRN3
ExoCarta ExoCarta_29966
Entrez Gene 29966
HGNC 15720
MIM 614766
UniProt Q13033  
 STRN3 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for STRN3
Molecular Function
    armadillo repeat domain binding GO:0070016 IPI
    protein complex binding GO:0032403 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    calmodulin binding GO:0005516 NAS
    protein phosphatase 2A binding GO:0051721 IDA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of transcription, DNA-templated GO:0045892 IEA
    response to estradiol GO:0032355 ISS
    negative regulation of intracellular estrogen receptor signaling pathway GO:0033147 ISS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 IDA
    nucleus GO:0005634 IDA
    protein complex GO:0043234 ISS
    plasma membrane GO:0005886 IDA
    dendrite GO:0030425 ISS
    cytoplasm GO:0005737 IDA
    Golgi apparatus GO:0005794 IDA
    nucleoplasm GO:0005654 IDA
    neuronal cell body GO:0043025 ISS
 Experiment description of studies that identified STRN3 in exosomes
1
Experiment ID 207
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for STRN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STRIP1 85369
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 SLMAP  
Affinity Capture-MS Homo sapiens
3 STK24 8428
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PPP2R4 5524
Affinity Capture-Western Homo sapiens
5 STK25 10494
Affinity Capture-MS Homo sapiens
6 CCT3 7203
Affinity Capture-MS Homo sapiens
7 FLJ21168  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 CCT2 10576
Affinity Capture-MS Homo sapiens
9 STRN4 29888
Affinity Capture-MS Homo sapiens
10 T3JAM  
Affinity Capture-MS Homo sapiens
11 TCP1 6950
Affinity Capture-MS Homo sapiens
12 FAM40B  
Affinity Capture-MS Homo sapiens
13 MCC 4163
Affinity Capture-MS Homo sapiens
14 STRN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 CCT4 10575
Affinity Capture-MS Homo sapiens
16 STK26 51765
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PREI3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 CCT7 10574
Affinity Capture-MS Homo sapiens
19 CCT5 22948
Affinity Capture-MS Homo sapiens
20 PDCD10 11235
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CCT6A 908
Affinity Capture-MS Homo sapiens
22 DKFZp547A023  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
23 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 FGFR1OP2  
Affinity Capture-MS Homo sapiens
25 CCT8 10694
Affinity Capture-MS Homo sapiens
26 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 PPP2CB 5516
Affinity Capture-MS Homo sapiens
28 CTTNBP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which STRN3 is involved
No pathways found





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