Gene description for PPP2R5C
Gene name
protein phosphatase 2, regulatory subunit B', gamma
Gene symbol
PPP2R5C
Other names/aliases
B56G PR61G
Species
Homo sapiens
Database cross references - PPP2R5C
ExoCarta
ExoCarta_5527
Entrez Gene
5527
HGNC
9311
MIM
601645
UniProt
Q13362
PPP2R5C identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells
25944692
Ovarian cancer cells
23333927
Ovarian cancer cells
23333927
Gene ontology annotations for PPP2R5C
Experiment description of studies that identified PPP2R5C in exosomes
1
Experiment ID
224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
25944692
Organism
Homo sapiens
Experiment description
Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors
Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name
Oncotarget
Publication year
2015
Sample
Neuroblastoma cells
Sample name
SH-SY5Y
Isolation/purification methods
Differential centrifugation Ultracentrifugation OptiPrep density gradient
Flotation density
1.10 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry Western blotting
2
Experiment ID
211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
IGROV1
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
3
Experiment ID
212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
OVCAR-3
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for PPP2R5C
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
AXIN1
Invivo
Homo sapiens
2
PPP2CA
5515
Affinity Capture-Western
Homo sapiens
Affinity Capture-MS
Homo sapiens
3
PPP2R5A
Affinity Capture-Western
Homo sapiens
4
PPP2R1B
5519
Affinity Capture-MS
Homo sapiens
5
PPP2R1A
5518
Affinity Capture-MS
Homo sapiens
6
PRKCD
5580
Invitro
Homo sapiens
Invivo
Homo sapiens
7
CCNG2
Affinity Capture-Western
Homo sapiens
View the network
image/svg+xml
Pathways in which PPP2R5C is involved