Gene description for CCDC6
Gene name coiled-coil domain containing 6
Gene symbol CCDC6
Other names/aliases D10S170
H4
PTC
TPC
TST1
Species Homo sapiens
 Database cross references - CCDC6
ExoCarta ExoCarta_8030
Entrez Gene 8030
HGNC 18782
MIM 601985
UniProt Q16204  
 CCDC6 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for CCDC6
Molecular Function
    structural constituent of cytoskeleton GO:0005200 TAS
    SH3 domain binding GO:0017124 IEA
    protein binding GO:0005515 IPI
Biological Process
    biological_process GO:0008150 ND
Subcellular Localization
    cytoplasm GO:0005737 IDA
    cytoskeleton GO:0005856 IEA
 Experiment description of studies that identified CCDC6 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for CCDC6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPP4C 5531
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CCDC6 is involved
No pathways found





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