Gene description for P2RY2
Gene name purinergic receptor P2Y, G-protein coupled, 2
Gene symbol P2RY2
Other names/aliases HP2U
P2RU1
P2U
P2U1
P2UR
P2Y2
P2Y2R
Species Homo sapiens
 Database cross references - P2RY2
ExoCarta ExoCarta_5029
Entrez Gene 5029
HGNC 8541
MIM 600041
UniProt P41231  
 P2RY2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for P2RY2
Molecular Function
    receptor activity GO:0004872 TAS
    G-protein coupled purinergic nucleotide receptor activity GO:0045028 IEA
Biological Process
    positive regulation of mucus secretion GO:0070257 IEA
    regulation of vasodilation GO:0042312 IEA
    phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 IEA
    cellular ion homeostasis GO:0006873 TAS
    G-protein coupled purinergic nucleotide receptor signaling pathway GO:0035589 IEA
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified P2RY2 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for P2RY2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ITGAV 3685
Invivo Homo sapiens
Invitro Homo sapiens
2 CD47 961
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
3 ITGB5 3693
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
4 ITGB3 3690
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which P2RY2 is involved
PathwayEvidenceSource
G alpha (q) signalling events TAS Reactome
G alpha (q) signalling events TAS Reactome
P2Y receptors TAS Reactome





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