Gene description for SERPINE1
Gene name	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Gene symbol	SERPINE1
Other names/aliases	PAI PAI-1 PAI1 PLANH1
Species	Homo sapiens
Database cross references - SERPINE1
ExoCarta	ExoCarta_5054
Entrez Gene	5054
HGNC	8583
MIM	173360
UniProt	P05121
SERPINE1 identified in exosomes derived from the following tissue/cell type
Keratinocytes	19530224
Keratinocytes	19530224
Melanoma cells	25950383
Mesenchymal stem cells	Unpublished / Not applicable
Trophoblast cells	21276792

Gene ontology annotations for SERPINE1

Molecular Function     serine-type endopeptidase inhibitor activity GO:0004867 IDA     protease binding GO:0002020 IPI     receptor binding GO:0005102 IPI     protein binding GO:0005515 IPI Biological Process     positive regulation of interleukin-8 production GO:0032757 IMP     extracellular matrix organization GO:0030198 TAS     transcription, DNA-templated GO:0006351 TAS     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     angiogenesis GO:0001525 IEP     negative regulation of blood coagulation GO:0030195 IC     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     negative regulation of wound healing GO:0061045 IC     defense response to Gram-negative bacterium GO:0050829 IGI     negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IMP     negative regulation of smooth muscle cell-matrix adhesion GO:2000098 IDA     gene expression GO:0010467 TAS     negative regulation of cell adhesion mediated by integrin GO:0033629 IDA     platelet activation GO:0030168 TAS     positive regulation of blood coagulation GO:0030194 IMP     platelet degranulation GO:0002576 TAS     positive regulation of receptor-mediated endocytosis GO:0048260 IDA     negative regulation of fibrinolysis GO:0051918 IDA     negative regulation of plasminogen activation GO:0010757 IMP     regulation of cell proliferation GO:0042127 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 TAS     circadian rhythm GO:0007623 TAS     chronological cell aging GO:0001300 IEP     blood coagulation GO:0007596 TAS     negative regulation of cell migration GO:0030336 IDA     negative regulation of endopeptidase activity GO:0010951 IDA     regulation of receptor activity GO:0010469 IDA     negative regulation of smooth muscle cell migration GO:0014912 IDA     positive regulation of angiogenesis GO:0045766 IMP     fibrinolysis GO:0042730 TAS     positive regulation of monocyte chemotaxis GO:0090026 IMP     cellular response to lipopolysaccharide GO:0071222 IMP     negative regulation of vascular wound healing GO:0061044 IGI     positive regulation of inflammatory response GO:0050729 IGI     positive regulation of leukotriene production involved in inflammatory response GO:0035491 IMP     negative regulation of endothelial cell apoptotic process GO:2000352 IMP Subcellular Localization     extracellular matrix GO:0031012 IDA     platelet alpha granule lumen GO:0031093 TAS     plasma membrane GO:0005886 TAS     extracellular space GO:0005615 IDA     extracellular exosome GO:0070062 IDA     extracellular region GO:0005576 TAS