Gene description for DKK3
Gene name dickkopf WNT signaling pathway inhibitor 3
Gene symbol DKK3
Other names/aliases REIC
RIG
Species Homo sapiens
 Database cross references - DKK3
ExoCarta ExoCarta_27122
Entrez Gene 27122
HGNC 2893
MIM 605416
UniProt Q9UBP4  
 DKK3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for DKK3
Biological Process
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of cortisol biosynthetic process GO:2000065 IDA
    negative regulation of aldosterone biosynthetic process GO:0032348 IDA
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IDA
    anatomical structure morphogenesis GO:0009653 TAS
    adrenal gland development GO:0030325 IEP
Subcellular Localization
    extracellular space GO:0005615 TAS
 Experiment description of studies that identified DKK3 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for DKK3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DKK3 is involved
No pathways found





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