Gene description for MYDGF
Gene name myeloid-derived growth factor
Gene symbol MYDGF
Other names/aliases C19orf10
EUROIMAGE1875335
IL25
IL27
IL27w
R33729_1
SF20
Species Homo sapiens
 Database cross references - MYDGF
ExoCarta ExoCarta_56005
Entrez Gene 56005
HGNC 16948
MIM 606746
UniProt Q969H8  
 MYDGF identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for MYDGF
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of angiogenesis GO:0045766 IDA
    positive regulation of protein kinase B signaling GO:0051897 ISS
    apoptotic process GO:0006915 IEA
    positive regulation of endothelial cell proliferation GO:0001938 IDA
    negative regulation of apoptotic process GO:0043066 ISS
    IRE1-mediated unfolded protein response GO:0036498 TAS
    positive regulation of protein phosphorylation GO:0001934 ISS
    endoplasmic reticulum unfolded protein response GO:0030968 TAS
    positive regulation of MAPK cascade GO:0043410 ISS
    positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 ISS
    cellular protein metabolic process GO:0044267 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS
    angiogenesis GO:0001525 IEA
    cellular response to brefeldin A GO:0071238 ISS
Subcellular Localization
    extracellular space GO:0005615 IDA
    endoplasmic reticulum lumen GO:0005788 TAS
    extracellular exosome GO:0070062 IDA
    endoplasmic reticulum-Golgi intermediate compartment GO:0005793 IEA
 Experiment description of studies that identified MYDGF in exosomes
1
Experiment ID 207
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
EM
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
EV Biophysical techniques
TSG101|HSP70
EV Cytosolic markers
FLOT1
EV Membrane markers
VDAC
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MYDGF
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BAG6 7917
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MYDGF is involved
PathwayEvidenceSource
XBP1(S) activates chaperone genes TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here