Gene description for Abr
Gene name active BCR-related gene
Gene symbol Abr
Other names/aliases -
Species Mus musculus
 Database cross references - Abr
ExoCarta ExoCarta_109934
Vesiclepedia VP_109934
Entrez Gene 109934
UniProt Q5SSL4  
 Abr identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
Mast cells 17486113    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Abr
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 ISO
    guanyl-nucleotide exchange factor activity GO:0005085 ISS
    GTPase activator activity GO:0005096 IDA
    GTPase activator activity GO:0005096 IGI
    GTPase activator activity GO:0005096 ISO
    GTPase activator activity GO:0005096 ISS
    GTPase activator activity GO:0005096 TAS
Biological Process
    negative regulation of cellular extravasation GO:0002692 IMP
    phagocytosis GO:0006909 IGI
    brain development GO:0007420 IGI
    cell migration GO:0016477 IGI
    actin cytoskeleton organization GO:0030036 IGI
    response to lipopolysaccharide GO:0032496 IMP
    intracellular signal transduction GO:0035556 IEA
    inner ear morphogenesis GO:0042472 IGI
    regulation of vascular permeability GO:0043114 IMP
    neutrophil degranulation GO:0043312 IGI
    negative regulation of neutrophil degranulation GO:0043314 IGI
    negative regulation of inflammatory response GO:0050728 IMP
    positive regulation of phagocytosis GO:0050766 IGI
    modulation of chemical synaptic transmission GO:0050804 IDA
    modulation of chemical synaptic transmission GO:0050804 IMP
    neuromuscular process controlling balance GO:0050885 IGI
    establishment of localization in cell GO:0051649 IGI
    negative regulation of blood vessel remodeling GO:0060313 IMP
    activation of GTPase activity GO:0090630 ISO
    activation of GTPase activity GO:0090630 ISS
    macrophage migration GO:1905517 IGI
    negative regulation of macrophage migration GO:1905522 IGI
Subcellular Localization
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
    membrane GO:0016020 IBA
    axon GO:0030424 IEA
    dendritic spine GO:0043197 IEA
    Schaffer collateral - CA1 synapse GO:0098685 IDA
    Schaffer collateral - CA1 synapse GO:0098685 IMP
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    glutamatergic synapse GO:0098978 ISO
    postsynaptic density, intracellular component GO:0099092 ISO
 Experiment description of studies that identified Abr in exosomes
1
Experiment ID 907
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
3
Experiment ID 908
MISEV standards
EM
Biophysical techniques
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
HSPA5
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Abr
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MGA  
Affinity Capture-MS Homo sapiens
2 CCAR1 55749
Affinity Capture-MS Homo sapiens
3 IMPDH2 3615
Affinity Capture-MS Homo sapiens
4 SMARCC1 6599
Affinity Capture-MS Homo sapiens
5 MCM3 4172
Affinity Capture-MS Homo sapiens
6 KCTD12 115207
Affinity Capture-MS Homo sapiens
7 HAX1  
Affinity Capture-MS Homo sapiens
8 RAC1 5879
FRET Homo sapiens
9 TOMM40 10452
Affinity Capture-MS Homo sapiens
10 ATPIF1 93974
Affinity Capture-MS Homo sapiens
11 CHCHD2  
Affinity Capture-MS Homo sapiens
12 Rac1 19353
Affinity Capture-Western Mus musculus
13 CKAP4 10970
Affinity Capture-MS Homo sapiens
14 DOCK4 9732
Affinity Capture-MS Homo sapiens
15 PRRC2A 7916
Affinity Capture-MS Homo sapiens
16 Dlg4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
17 CHCHD3 54927
Affinity Capture-MS Homo sapiens
18 BOLA2 552900
Affinity Capture-MS Homo sapiens
19 PPP1R13L 10848
Affinity Capture-MS Homo sapiens
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