Gene description for MICA
Gene name MHC class I polypeptide-related sequence A
Gene symbol MICA
Other names/aliases MIC-A
Species Homo sapiens
 Database cross references - MICA
ExoCarta ExoCarta_100507436
Entrez Gene 100507436
HGNC 7090
MIM 600169
UniProt Q29983  
 MICA identified in exosomes derived from the following tissue/cell type
Trophoblast cells 21276792    
 Gene ontology annotations for MICA
Molecular Function
    antigen binding GO:0003823 IBA
    beta-2-microglobulin binding GO:0030881 IDA
    natural killer cell lectin-like receptor binding GO:0046703 IPI
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of natural killer cell mediated cytotoxicity GO:0045953 IMP
    gamma-delta T cell activation GO:0046629 IDA
    cytolysis GO:0019835 IEA
    viral process GO:0016032 IEA
    immune response to tumor cell GO:0002418 IDA
    T cell mediated cytotoxicity GO:0001913 IDA
    negative regulation of natural killer cell activation GO:0032815 IDA
    defense response to virus GO:0051607 IDA
    cellular response to DNA damage stimulus GO:0006974 IDA
    natural killer cell mediated cytotoxicity GO:0042267 IDA
    response to heat GO:0009408 IDA
    antigen processing and presentation GO:0019882 IBA
    defense response to bacterium GO:0042742 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    cytoplasm GO:0005737 IEA
    integral component of plasma membrane GO:0005887 IDA
    extracellular space GO:0005615 IDA
    cell surface GO:0009986 IDA
 Experiment description of studies that identified MICA in exosomes
Experiment ID 121
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 21276792    
Organism Homo sapiens
Experiment description Morphologic and proteomic characterization of exosomes released by cultured extravillous trophoblast cells.
Authors Atay S, Gercel-Taylor C, Kesimer M, Taylor DD.
Journal name ECR
Publication year 2011
Sample Trophoblast cells
Sample name Sw71
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for MICA
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MICA is involved
No pathways found

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