Gene description for ARL13B
Gene name ADP-ribosylation factor-like 13B
Gene symbol ARL13B
Other names/aliases ARL2L1
JBTS8
Species Homo sapiens
 Database cross references - ARL13B
ExoCarta ExoCarta_200894
Vesiclepedia VP_200894
Entrez Gene 200894
HGNC 25419
MIM 608922
UniProt Q3SXY8  
 ARL13B identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ARL13B
Molecular Function
    GTPase activity GO:0003924 IEA
    protein binding GO:0005515 IPI
    GTP binding GO:0005525 IEA
Biological Process
    heart looping GO:0001947 IEA
    smoothened signaling pathway GO:0007224 ISS
    dorsal/ventral pattern formation GO:0009953 IEA
    neural tube patterning GO:0021532 ISS
    interneuron migration from the subpallium to the cortex GO:0021830 ISS
    formation of radial glial scaffolds GO:0021943 ISS
    cilium assembly GO:0060271 ISS
    left/right axis specification GO:0070986 IEA
    receptor localization to non-motile cilium GO:0097500 IBA
    non-motile cilium assembly GO:1905515 IBA
    non-motile cilium assembly GO:1905515 ISS
Subcellular Localization
    cytosol GO:0005829 TAS
    cilium GO:0005929 IDA
    cilium GO:0005929 ISS
    cilium GO:0005929 TAS
    axoneme GO:0005930 IEA
    motile cilium GO:0031514 IBA
    ciliary membrane GO:0060170 IBA
    ciliary membrane GO:0060170 ISS
    non-motile cilium GO:0097730 IBA
 Experiment description of studies that identified ARL13B in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ARL13B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 C2CD2L 9854
Two-hybrid Homo sapiens
2 LOC100507537  
Two-hybrid Homo sapiens
3 GJD3  
Proximity Label-MS Homo sapiens
4 LCK 3932
Proximity Label-MS Homo sapiens
5 CSGALNACT2 55454
Two-hybrid Homo sapiens
6 STK25 10494
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SLC35A1 10559
Two-hybrid Homo sapiens
8 OCLN 100506658
Proximity Label-MS Homo sapiens
9 PAEP  
Two-hybrid Homo sapiens
10 LAMP3  
Proximity Label-MS Homo sapiens
11 ATG9A 79065
Proximity Label-MS Homo sapiens
12 GJA1 2697
Proximity Label-MS Homo sapiens
13 EMP1  
Two-hybrid Homo sapiens
14 CD53 963
Two-hybrid Homo sapiens
15 TUSC5  
Two-hybrid Homo sapiens
16 PTPN9 5780
Two-hybrid Homo sapiens
17 CYB561D2 11068
Two-hybrid Homo sapiens
18 AIG1  
Two-hybrid Homo sapiens
19 LAMP2 3920
Proximity Label-MS Homo sapiens
20 GOSR2 9570
Two-hybrid Homo sapiens
21 NINJ2  
Two-hybrid Homo sapiens
22 MUCL1  
Two-hybrid Homo sapiens
23 ANKRD50 57182
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 GIMAP1  
Two-hybrid Homo sapiens
25 LAMTOR1 55004
Proximity Label-MS Homo sapiens
26 TEX264 51368
Two-hybrid Homo sapiens
27 ALG3 10195
Two-hybrid Homo sapiens
28 CLEC4G  
Two-hybrid Homo sapiens
29 STX1A 6804
Two-hybrid Homo sapiens
30 TMEM65 157378
Two-hybrid Homo sapiens
31 IFT52 51098
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 C4orf3  
Two-hybrid Homo sapiens
33 RAB3B 5865
Proximity Label-MS Homo sapiens
34 MMD  
Two-hybrid Homo sapiens
35 STX7 8417
Proximity Label-MS Homo sapiens
36 CFHR5  
Two-hybrid Homo sapiens
37 MAPK14 1432
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SLC31A1 1317
Affinity Capture-MS Homo sapiens
39 CCL4L2  
Two-hybrid Homo sapiens
40 KCNJ2 3759
Two-hybrid Homo sapiens
41 IFT81 28981
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 TM6SF2  
Two-hybrid Homo sapiens
43 TSPO2  
Two-hybrid Homo sapiens
44 LPAR3  
Two-hybrid Homo sapiens
45 GIMAP5  
Two-hybrid Homo sapiens
46 TMEM97 27346
Two-hybrid Homo sapiens
47 STX6 10228
Proximity Label-MS Homo sapiens
48 SACM1L 22908
Two-hybrid Homo sapiens
49 SMAGP  
Two-hybrid Homo sapiens
50 RAB35 11021
Proximity Label-MS Homo sapiens
51 ACSF2 80221
Two-hybrid Homo sapiens
52 MOSPD3  
Two-hybrid Homo sapiens
53 MCAM 4162
Proximity Label-MS Homo sapiens
54 ITGAM 3684
Two-hybrid Homo sapiens
55 LEPROTL1 23484
Two-hybrid Homo sapiens
56 MARCKS 4082
Proximity Label-MS Homo sapiens
57 SLC35B1 10237
Two-hybrid Homo sapiens
58 FASTKD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 TMEM254  
Two-hybrid Homo sapiens
60 YIPF6 286451
Two-hybrid Homo sapiens
61 TMEM190  
Two-hybrid Homo sapiens
62 CLDN8  
Two-hybrid Homo sapiens
63 TMEM54  
Two-hybrid Homo sapiens
64 IPO11 51194
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 IFT27 11020
Affinity Capture-MS Homo sapiens
66 CLEC7A  
Two-hybrid Homo sapiens
67 CXADR 1525
Proximity Label-MS Homo sapiens
68 FUNDC2 65991
Two-hybrid Homo sapiens
69 JAGN1 84522
Two-hybrid Homo sapiens
70 TMEM43 79188
Two-hybrid Homo sapiens
71 LYN 4067
Proximity Label-MS Homo sapiens
72 UBE2I 7329
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
73 RAB4A 5867
Proximity Label-MS Homo sapiens
74 PDXDC1 23042
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 DNAJC5 80331
Proximity Label-MS Homo sapiens
76 SLC39A2  
Two-hybrid Homo sapiens
77 MKRN2 23609
Affinity Capture-RNA Homo sapiens
78 TNPO2 30000
Affinity Capture-MS Homo sapiens
79 PDCD11 22984
Affinity Capture-MS Homo sapiens
80 MYADML2  
Two-hybrid Homo sapiens
81 COL8A2 1296
Two-hybrid Homo sapiens
82 SLC2A5 6518
Two-hybrid Homo sapiens
83 BRICD5  
Two-hybrid Homo sapiens
84 VAMP1 6843
Two-hybrid Homo sapiens
85 PDZK1IP1 10158
Two-hybrid Homo sapiens
86 TNFRSF10C  
Two-hybrid Homo sapiens
87 TMEM121  
Two-hybrid Homo sapiens
88 CTDSPL 10217
Proximity Label-MS Homo sapiens
89 SLC7A1 6541
Affinity Capture-MS Homo sapiens
90 CLN6  
Two-hybrid Homo sapiens
91 CDIPT 10423
Two-hybrid Homo sapiens
92 CCL4  
Two-hybrid Homo sapiens
93 TMEM14C 51522
Two-hybrid Homo sapiens
94 TTI1 9675
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 TMEM128  
Two-hybrid Homo sapiens
96 TTC30A 92104
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 GJB2  
Two-hybrid Homo sapiens
98 BMP10  
Two-hybrid Homo sapiens
99 DENND6A 201627
Proximity Label-MS Homo sapiens
100 RAB5A 5868
Proximity Label-MS Homo sapiens
101 PANX1 24145
Proximity Label-MS Homo sapiens
102 RTP2  
Two-hybrid Homo sapiens
103 KLRG1  
Two-hybrid Homo sapiens
104 TMEM187  
Two-hybrid Homo sapiens
105 THSD7B  
Two-hybrid Homo sapiens
106 HMOX2 3163
Two-hybrid Homo sapiens
107 LAMP1 3916
Proximity Label-MS Homo sapiens
108 PTPRH 5794
Proximity Label-MS Homo sapiens
109 AOC3 8639
Two-hybrid Homo sapiens
110 ICMT  
Two-hybrid Homo sapiens
111 VSTM1  
Two-hybrid Homo sapiens
112 FKBP8 23770
Two-hybrid Homo sapiens
113 WFDC2  
Two-hybrid Homo sapiens
114 ARF6 382
Proximity Label-MS Homo sapiens
115 ORMDL3 94103
Two-hybrid Homo sapiens
116 FXYD6  
Two-hybrid Homo sapiens
117 FAM63B 54629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 B4GALNT2  
Two-hybrid Homo sapiens
119 VAMP2 6844
Two-hybrid Homo sapiens
120 ORMDL1 94101
Two-hybrid Homo sapiens
121 NRM 11270
Two-hybrid Homo sapiens
122 TMEM86B  
Two-hybrid Homo sapiens
123 PRKACA 5566
Proximity Label-MS Homo sapiens
124 FAXDC2  
Two-hybrid Homo sapiens
125 TMEM229B  
Two-hybrid Homo sapiens
126 IFT46 56912
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 RAB9A 9367
Proximity Label-MS Homo sapiens
128 TMEM11 8834
Two-hybrid Homo sapiens
129 AQP10  
Two-hybrid Homo sapiens
130 SLC13A3 64849
Two-hybrid Homo sapiens
131 PMP22  
Two-hybrid Homo sapiens
132 ENTPD3  
Two-hybrid Homo sapiens
133 RHOB 388
Proximity Label-MS Homo sapiens
134 BNIP3 664
Two-hybrid Homo sapiens
135 CCDC167  
Two-hybrid Homo sapiens
136 LPPR2  
Two-hybrid Homo sapiens
137 NKG7  
Two-hybrid Homo sapiens
138 PPAPDC1A  
Two-hybrid Homo sapiens
139 ZDHHC15 158866
Two-hybrid Homo sapiens
140 FLOT1 10211
Proximity Label-MS Homo sapiens
141 MALL  
Two-hybrid Homo sapiens
142 SLTM 79811
Affinity Capture-MS Homo sapiens
143 GEMIN4 50628
Affinity Capture-MS Homo sapiens
144 IFT22 64792
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
145 RAB18 22931
Affinity Capture-MS Homo sapiens
146 C1GALT1 56913
Two-hybrid Homo sapiens
147 ARV1  
Affinity Capture-MS Homo sapiens
148 CMTM7  
Two-hybrid Homo sapiens
149 CD302 9936
Two-hybrid Homo sapiens
150 ANKFY1 51479
Proximity Label-MS Homo sapiens
151 GAD2  
Two-hybrid Homo sapiens
152 PLP1 5354
Two-hybrid Homo sapiens
153 TMEM218  
Two-hybrid Homo sapiens
154 VAC14 55697
Affinity Capture-MS Homo sapiens
155 MAL2 114569
Two-hybrid Homo sapiens
156 VAMP4 8674
Two-hybrid Homo sapiens
157 CMTM3 123920
Two-hybrid Homo sapiens
158 EBP  
Two-hybrid Homo sapiens
159 C11orf52 91894
Proximity Label-MS Homo sapiens
160 SLC38A7 55238
Two-hybrid Homo sapiens
161 GORASP1 64689
Proximity Label-MS Homo sapiens
162 TMUB2  
Two-hybrid Homo sapiens
163 TTC26 79989
Affinity Capture-MS Homo sapiens
164 PLN  
Two-hybrid Homo sapiens
165 RAB2A 5862
Proximity Label-MS Homo sapiens
166 SPN 6693
Two-hybrid Homo sapiens
167 TMEM79  
Two-hybrid Homo sapiens
168 CD151 977
Two-hybrid Homo sapiens
169 GPR37L1  
Two-hybrid Homo sapiens
170 RAB11A 8766
Proximity Label-MS Homo sapiens
171 EPHA2 1969
Proximity Label-MS Homo sapiens
172 PGAP2  
Two-hybrid Homo sapiens
173 KRAS 3845
Proximity Label-MS Homo sapiens
174 RAB5C 5878
Proximity Label-MS Homo sapiens
175 NAT8  
Two-hybrid Homo sapiens
176 PRB1  
Two-hybrid Homo sapiens
177 CLDN4 1364
Two-hybrid Homo sapiens
178 ANKRD46 157567
Two-hybrid Homo sapiens
179 CAV1 857
Proximity Label-MS Homo sapiens
180 S100A2 6273
Two-hybrid Homo sapiens
181 CXCL16 58191
Two-hybrid Homo sapiens
182 IFT74 80173
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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