Gene description for DEPTOR
Gene name DEP domain containing MTOR-interacting protein
Gene symbol DEPTOR
Other names/aliases DEP.6
DEPDC6
Species Homo sapiens
 Database cross references - DEPTOR
ExoCarta ExoCarta_64798
Vesiclepedia VP_64798
Entrez Gene 64798
HGNC 22953
MIM 612974
UniProt Q8TB45  
 DEPTOR identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for DEPTOR
Molecular Function
    protein kinase inhibitor activity GO:0004860 IDA
    guanyl-nucleotide exchange factor activity GO:0005085 IBA
    GTPase activator activity GO:0005096 IBA
    protein binding GO:0005515 IPI
    protein serine/threonine kinase inhibitor activity GO:0030291 IDA
    phosphatidic acid binding GO:0070300 IDA
Biological Process
    negative regulation of protein kinase activity GO:0006469 IBA
    negative regulation of protein kinase activity GO:0006469 IMP
    G protein-coupled receptor signaling pathway GO:0007186 IBA
    positive regulation of autophagy GO:0010508 IDA
    negative regulation of TOR signaling GO:0032007 IMP
    intracellular signal transduction GO:0035556 IEA
    negative regulation of cell size GO:0045792 IMP
    negative regulation of TORC2 signaling GO:1903940 IBA
    negative regulation of TORC2 signaling GO:1903940 IDA
    negative regulation of TORC2 signaling GO:1903940 IGI
    negative regulation of TORC1 signaling GO:1904262 IBA
    negative regulation of TORC1 signaling GO:1904262 IDA
    negative regulation of TORC1 signaling GO:1904262 IGI
    regulation of extrinsic apoptotic signaling pathway GO:2001236 IMP
Subcellular Localization
    lysosomal membrane GO:0005765 IDA
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified DEPTOR in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DEPTOR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CUL1 8454
Affinity Capture-Western Homo sapiens
2 BTRC 8945
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 FBXW11  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
4 XPO1 7514
Affinity Capture-MS Homo sapiens
5 PSME3 10197
Two-hybrid Homo sapiens
6 TRIM41 90933
Two-hybrid Homo sapiens
7 FBXO25  
Biochemical Activity Homo sapiens
8 CUL5 8065
Biochemical Activity Homo sapiens
9 RPTOR 57521
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 RICTOR 253260
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 APP 351
Reconstituted Complex Homo sapiens
12 NXF1 10482
Affinity Capture-RNA Homo sapiens
13 CCDC110  
Two-hybrid Homo sapiens
14 RPS6KB1 6198
Biochemical Activity Homo sapiens
15 NUMB 8650
Affinity Capture-Western Homo sapiens
16 TRIM16 10626
Affinity Capture-Western Homo sapiens
17 MTOR 2475
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
18 ANKRD11 29123
Two-hybrid Homo sapiens
19 FBXW7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 CHKA 1119
Biochemical Activity Homo sapiens
21 MLST8 64223
Affinity Capture-MS Homo sapiens
22 TRAF1 7185
Two-hybrid Homo sapiens
23 LNX1  
Reconstituted Complex Homo sapiens
24 RPS6KA1 6195
Biochemical Activity Homo sapiens
View the network image/svg+xml
 Pathways in which DEPTOR is involved
No pathways found





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