Gene description for BTK
Gene name	Bruton agammaglobulinemia tyrosine kinase
Gene symbol	BTK
Other names/aliases	AGMX1 AT ATK BPK IMD1 PSCTK1 XLA
Species	Homo sapiens
Database cross references - BTK
ExoCarta	ExoCarta_695
Entrez Gene	695
HGNC	1133
MIM	300300
UniProt	Q06187
BTK identified in exosomes derived from the following tissue/cell type
Platelets	25332113
Platelets	25332113
Platelets	25332113
Thymus	23844026

Gene ontology annotations for BTK

Molecular Function     receptor binding GO:0005102 IBA     identical protein binding GO:0042802 IPI     ATP binding GO:0005524 TAS     metal ion binding GO:0046872 IEA     protein tyrosine kinase activity GO:0004713 TAS     phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 IDA     protein binding GO:0005515 IPI     non-membrane spanning protein tyrosine kinase activity GO:0004715 TAS Biological Process     B cell activation GO:0042113 TAS     peptidyl-tyrosine autophosphorylation GO:0038083 IBA     mesoderm development GO:0007498 TAS     adaptive immune response GO:0002250 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     cell maturation GO:0048469 IEA     regulation of cell proliferation GO:0042127 IBA     positive regulation of B cell differentiation GO:0045579 TAS     cellular response to molecule of fungal origin GO:0071226 IEA     T cell receptor signaling pathway GO:0050852 IBA     toll-like receptor signaling pathway GO:0002224 TAS     innate immune response GO:0045087 TAS     peptidyl-tyrosine phosphorylation GO:0018108 IDA     B cell receptor signaling pathway GO:0050853 TAS     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS     MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS     regulation of B cell apoptotic process GO:0002902 TAS     toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS     calcium-mediated signaling GO:0019722 TAS     toll-like receptor 4 signaling pathway GO:0034142 TAS     cellular response to reactive oxygen species GO:0034614 IEA     cell differentiation GO:0030154 IBA     apoptotic signaling pathway GO:0097190 TAS     intracellular signal transduction GO:0035556 TAS     protein phosphorylation GO:0006468 TAS     toll-like receptor 2 signaling pathway GO:0034134 TAS     histamine secretion by mast cell GO:0002553 IEA     transcription, DNA-templated GO:0006351 IEA     I-kappaB kinase/NF-kappaB signaling GO:0007249 IEA     regulation of B cell cytokine production GO:0002721 TAS     toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS Subcellular Localization     perinuclear region of cytoplasm GO:0048471 IEA     membrane raft GO:0045121 IDA     intracellular membrane-bounded organelle GO:0043231 IDA     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA     cytoplasm GO:0005737 TAS     cytosol GO:0005829 TAS     nucleus GO:0005634 TAS     cytoplasmic vesicle GO:0031410 IEA     plasma membrane GO:0005886 TAS     mast cell granule GO:0042629 IEA