Gene description for FCER1G
Gene name Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
Gene symbol FCER1G
Other names/aliases FCRG
Species Homo sapiens
 Database cross references - FCER1G
ExoCarta ExoCarta_2207
Entrez Gene 2207
HGNC 3611
MIM 147139
UniProt P30273  
 FCER1G identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for FCER1G
Molecular Function
    IgE binding GO:0019863 IEA
    protein binding GO:0005515 IPI
    IgE receptor activity GO:0019767 IEA
    IgG binding GO:0019864 IEA
Biological Process
    innate immune response GO:0045087 TAS
    immunoglobulin mediated immune response GO:0016064 IEA
    positive regulation of mast cell cytokine production GO:0032765 IEA
    neutrophil activation involved in immune response GO:0002283 IEA
    integrin-mediated signaling pathway GO:0007229 IEA
    Fc receptor mediated stimulatory signaling pathway GO:0002431 IEA
    serotonin secretion by platelet GO:0002554 IEA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IEA
    positive regulation of mast cell degranulation GO:0043306 IEA
    positive regulation of type IIa hypersensitivity GO:0001798 IEA
    mast cell activation GO:0045576 IEA
    positive regulation of type III hypersensitivity GO:0001805 IEA
    positive regulation of interleukin-6 production GO:0032755 IEA
    leukocyte migration GO:0050900 TAS
    positive regulation of phagocytosis GO:0050766 IEA
    positive regulation of tumor necrosis factor production GO:0032760 IEA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    regulation of platelet activation GO:0010543 IEA
    positive regulation of interleukin-10 production GO:0032733 IEA
    phagocytosis, engulfment GO:0006911 IEA
    blood coagulation GO:0007596 TAS
    platelet activation GO:0030168 TAS
    positive regulation of type I hypersensitivity GO:0001812 IEA
    defense response to bacterium GO:0042742 IEA
    neutrophil chemotaxis GO:0030593 IEA
    antigen processing and presentation of exogenous peptide antigen via MHC class I GO:0042590 IEA
    stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS
    negative regulation of mast cell apoptotic process GO:0033026 IEA
    protein localization to plasma membrane GO:0072659 IEA
Subcellular Localization
    cell surface GO:0009986 IDA
    Fc-epsilon receptor I complex GO:0032998 IEA
    external side of plasma membrane GO:0009897 IEA
    integral component of plasma membrane GO:0005887 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified FCER1G in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for FCER1G
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYN 4067
Invivo Homo sapiens
2 SYK 6850
Reconstituted Complex Homo sapiens
3 GP6 51206
Invivo Homo sapiens
4 PLCG2 5336
Invitro Homo sapiens
5 FCER1A  
Invivo Homo sapiens
6 NCR1  
Invivo Homo sapiens
View the network image/svg+xml



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