Gene description for FAM111A
Gene name family with sequence similarity 111, member A
Gene symbol FAM111A
Other names/aliases GCLEB
KCS2
Species Homo sapiens
 Database cross references - FAM111A
ExoCarta ExoCarta_63901
Vesiclepedia VP_63901
Entrez Gene 63901
HGNC 24725
MIM 615292
UniProt Q96PZ2  
 FAM111A identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for FAM111A
Molecular Function
    single-stranded DNA binding GO:0003697 IDA
    protein binding GO:0005515 IPI
    peptidase activity GO:0008233 IEA
Biological Process
    DNA replication GO:0006260 IBA
    DNA replication GO:0006260 IMP
    proteolysis GO:0006508 IDA
    DNA damage response GO:0006974 IDA
    protein autoprocessing GO:0016540 IDA
    replication fork processing GO:0031297 IDA
    negative regulation of viral genome replication GO:0045071 IMP
    protein-DNA covalent cross-linking repair GO:0106300 IDA
Subcellular Localization
    chromatin GO:0000785 IBA
    chromatin GO:0000785 IDA
    fibrillar center GO:0001650 IDA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified FAM111A in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for FAM111A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPL11 6135
Affinity Capture-MS Homo sapiens
2 RPL13 6137
Affinity Capture-MS Homo sapiens
3 ZNF668  
Affinity Capture-MS Homo sapiens
4 FGFBP1 9982
Affinity Capture-MS Homo sapiens
5 SURF6  
Affinity Capture-MS Homo sapiens
6 H1FNT  
Affinity Capture-MS Homo sapiens
7 RNF151  
Affinity Capture-MS Homo sapiens
8 NCSTN 23385
Affinity Capture-MS Homo sapiens
9 ABT1 29777
Affinity Capture-MS Homo sapiens
10 ZNF346  
Affinity Capture-MS Homo sapiens
11 TP53 7157
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 RPS2 6187
Affinity Capture-MS Homo sapiens
13 RPL3 6122
Affinity Capture-MS Homo sapiens
14 LIN28A  
Affinity Capture-MS Homo sapiens
15 RPL35 11224
Affinity Capture-MS Homo sapiens
16 RPL13A 23521
Affinity Capture-MS Homo sapiens
17 SRSF1 6426
Affinity Capture-MS Homo sapiens
18 RPL30 6156
Affinity Capture-MS Homo sapiens
19 NOP56 10528
Affinity Capture-MS Homo sapiens
20 NPM3 10360
Affinity Capture-MS Homo sapiens
21 RPL14 9045
Affinity Capture-MS Homo sapiens
22 RPL10 6134
Affinity Capture-MS Homo sapiens
23 SRSF5 6430
Affinity Capture-MS Homo sapiens
24 CDC23 8697
Affinity Capture-MS Homo sapiens
25 RPL4 6124
Affinity Capture-MS Homo sapiens
26 RPS10 6204
Affinity Capture-MS Homo sapiens
27 MKI67  
Affinity Capture-MS Homo sapiens
28 ZC3H10  
Affinity Capture-MS Homo sapiens
29 SRSF6 6431
Affinity Capture-MS Homo sapiens
30 PURG  
Affinity Capture-MS Homo sapiens
31 HIST1H2AM 8336
Affinity Capture-MS Homo sapiens
32 NEIL1  
Affinity Capture-MS Homo sapiens
33 RPL10A 4736
Affinity Capture-MS Homo sapiens
34 RBM4B  
Affinity Capture-MS Homo sapiens
35 PRKRA 8575
Affinity Capture-MS Homo sapiens
36 IL17B 27190
Affinity Capture-MS Homo sapiens
37 PARK2  
Affinity Capture-MS Homo sapiens
38 RPL31 6160
Affinity Capture-MS Homo sapiens
39 RPL7A 6130
Affinity Capture-MS Homo sapiens
40 CARKD 55739
Affinity Capture-MS Homo sapiens
41 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
42 RPS6 6194
Affinity Capture-MS Homo sapiens
43 RPL8 6132
Affinity Capture-MS Homo sapiens
44 RPL28 6158
Affinity Capture-MS Homo sapiens
45 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
46 RPL23A 6147
Affinity Capture-MS Homo sapiens
47 LYAR 55646
Affinity Capture-MS Homo sapiens
48 NPM1 4869
Affinity Capture-MS Homo sapiens
49 RPLP0 6175
Affinity Capture-MS Homo sapiens
50 MAGEB2 4113
Affinity Capture-MS Homo sapiens
51 SRP14 6727
Affinity Capture-MS Homo sapiens
52 ZC3H3  
Affinity Capture-MS Homo sapiens
53 MYBBP1A 10514
Affinity Capture-MS Homo sapiens
54 HIST1H2AE 3012
Affinity Capture-MS Homo sapiens
55 RPL19 6143
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAM111A is involved
No pathways found





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