Gene description for POLN
Gene name polymerase (DNA directed) nu
Gene symbol POLN
Other names/aliases POL4P
Species Homo sapiens
 Database cross references - POLN
ExoCarta ExoCarta_353497
Entrez Gene 353497
HGNC 18870
MIM 610887
UniProt Q7Z5Q5  
 POLN identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for POLN
Molecular Function
    protein binding GO:0005515 IPI
    cyclin binding GO:0030332 IPI
    DNA-directed DNA polymerase activity GO:0003887 IDA
    DNA binding GO:0003677 IEA
Biological Process
    DNA-dependent DNA replication GO:0006261 IEA
    interstrand cross-link repair GO:0036297 IMP
    translesion synthesis GO:0019985 IMP
    double-strand break repair via homologous recombination GO:0000724 IMP
Subcellular Localization
    nucleolus GO:0005730 IDA
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified POLN in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for POLN
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which POLN is involved
No pathways found





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