Gene description for HLA-DMB
Gene name major histocompatibility complex, class II, DM beta
Gene symbol HLA-DMB
Other names/aliases D6S221E
RING7
Species Homo sapiens
 Database cross references - HLA-DMB
ExoCarta ExoCarta_3109
Vesiclepedia VP_3109
Entrez Gene 3109
HGNC 4935
MIM 142856
UniProt P28068  
 HLA-DMB identified in exosomes derived from the following tissue/cell type
B cells 9685355    
 Gene ontology annotations for HLA-DMB
Molecular Function
    protein binding GO:0005515 IPI
    MHC class II protein complex binding GO:0023026 IBA
    MHC class II protein complex binding GO:0023026 IDA
    peptide antigen binding GO:0042605 IBA
Biological Process
    adaptive immune response GO:0002250 IEA
    MHC class II protein complex assembly GO:0002399 IMP
    peptide antigen assembly with MHC class II protein complex GO:0002503 IBA
    peptide antigen assembly with MHC class II protein complex GO:0002503 IDA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IBA
    antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 IMP
    positive regulation of T cell proliferation GO:0042102 IMP
    positive regulation of immune response GO:0050778 IBA
    positive regulation of T cell activation GO:0050870 IBA
    positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001190 IMP
Subcellular Localization
    lysosomal membrane GO:0005765 IBA
    lysosomal membrane GO:0005765 IDA
    lysosomal membrane GO:0005765 TAS
    late endosome membrane GO:0031902 IBA
    late endosome membrane GO:0031902 IDA
    MHC class II protein complex GO:0042613 IBA
    MHC class II protein complex GO:0042613 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified HLA-DMB in exosomes
1
Experiment ID 16
MISEV standards
✔
EM
Biophysical techniques
✔
MHCII|CD86|LAMP1|LAMP2|CD63|CD81|CD82|ICAM1|TFRC
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 9685355    
Organism Homo sapiens
Experiment description Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes.
Authors "Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, Geuze HJ"
Journal name JBC
Publication year 1998
Sample B cells
Sample name RN (HLA-DR15+)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.12-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for HLA-DMB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UFSP2 55325
Affinity Capture-MS Homo sapiens
2 C1orf27 54953
Affinity Capture-MS Homo sapiens
3 HTR3A  
Affinity Capture-MS Homo sapiens
4 SLC30A9 10463
Affinity Capture-MS Homo sapiens
5 KLRC3  
Affinity Capture-MS Homo sapiens
6 DECR2 26063
Affinity Capture-MS Homo sapiens
7 ABCB6 10058
Affinity Capture-MS Homo sapiens
8 TMBIM6 7009
Affinity Capture-MS Homo sapiens
9 CLGN 1047
Affinity Capture-MS Homo sapiens
10 CHRNA4  
Affinity Capture-MS Homo sapiens
11 CANX 821
Affinity Capture-MS Homo sapiens
12 SLC25A29  
Affinity Capture-MS Homo sapiens
13 FASTKD1  
Affinity Capture-MS Homo sapiens
14 DHRS7 51635
Affinity Capture-MS Homo sapiens
15 CTPS2 56474
Affinity Capture-MS Homo sapiens
16 ATP1A3 478
Affinity Capture-MS Homo sapiens
17 HLA-DRA 3122
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 EXTL3 2137
Affinity Capture-MS Homo sapiens
19 AP3M1 26985
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 ARFGEF1 10565
Affinity Capture-MS Homo sapiens
21 RAB29 8934
Affinity Capture-MS Homo sapiens
22 CUL3 8452
Two-hybrid Homo sapiens
23 PHOSPHO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 TMEM67 91147
Affinity Capture-MS Homo sapiens
25 SLC27A6  
Affinity Capture-MS Homo sapiens
26 ACSL4 2182
Affinity Capture-MS Homo sapiens
27 TUBA1A 7846
Affinity Capture-MS Homo sapiens
28 FDFT1 2222
Affinity Capture-MS Homo sapiens
29 PDZD8 118987
Affinity Capture-MS Homo sapiens
30 CYP51A1 1595
Affinity Capture-MS Homo sapiens
31 TAPBP 6892
Affinity Capture-MS Homo sapiens
32 VRK2 7444
Affinity Capture-MS Homo sapiens
33 ACVR1B 91
Affinity Capture-MS Homo sapiens
34 ARL5B  
Affinity Capture-MS Homo sapiens
35 RETSAT 54884
Affinity Capture-MS Homo sapiens
36 SLC27A3 11000
Affinity Capture-MS Homo sapiens
37 DHRS7B 25979
Affinity Capture-MS Homo sapiens
38 TCTN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 RDH11 51109
Affinity Capture-MS Homo sapiens
40 SMPD2 6610
Affinity Capture-MS Homo sapiens
41 PREB 10113
Affinity Capture-MS Homo sapiens
42 ABCA2 20
Affinity Capture-MS Homo sapiens
43 HLA-DQB1 3119
Affinity Capture-MS Homo sapiens
44 METTL9 51108
Affinity Capture-MS Homo sapiens
45 CD63 967
Affinity Capture-Western Homo sapiens
46 TEX264 51368
Affinity Capture-MS Homo sapiens
47 THEM6  
Affinity Capture-MS Homo sapiens
48 TEAD1  
Two-hybrid Homo sapiens
49 MDM2  
Two-hybrid Homo sapiens
50 CD82 3732
Affinity Capture-Western Homo sapiens
51 SLC12A2 6558
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HLA-DMB is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Immune System TAS Reactome
MHC class II antigen presentation TAS Reactome





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