Gene description for DNMT3A
Gene name	DNA (cytosine-5-)-methyltransferase 3 alpha
Gene symbol	DNMT3A
Other names/aliases	DNMT3A2 M.HsaIIIA TBRS
Species	Homo sapiens
Database cross references - DNMT3A
ExoCarta	ExoCarta_1788
Vesiclepedia	VP_1788
Entrez Gene	1788
HGNC	2978
MIM	602769
UniProt	Q9Y6K1
DNMT3A identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells	25944692

Gene ontology annotations for DNMT3A

Molecular Function     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA     DNA binding GO:0003677 EXP     chromatin binding GO:0003682 IEA     transcription corepressor activity GO:0003714 TAS     DNA (cytosine-5-)-methyltransferase activity GO:0003886 IBA     DNA (cytosine-5-)-methyltransferase activity GO:0003886 IDA     protein binding GO:0005515 IPI     identical protein binding GO:0042802 IPI     unmethylated CpG binding GO:0045322 EXP     metal ion binding GO:0046872 IEA     DNA (cytosine-5-)-methyltransferase activity, acting on CpN substrates GO:0051719 IEA     DNA (cytosine-5-)-methyltransferase activity, acting on CpNpG substrates GO:0051720 IEA     RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI     lncRNA binding GO:0106222 IDA     protein-cysteine methyltransferase activity GO:0106363 ISS Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IDA     negative regulation of transcription by RNA polymerase II GO:0000122 IMP     DNA methylation-dependent constitutive heterochromatin formation GO:0006346 IMP     spermatogenesis GO:0007283 IEA     response to xenobiotic stimulus GO:0009410 IEA     response to toxic substance GO:0009636 IEA     response to ionizing radiation GO:0010212 IEA     response to lead ion GO:0010288 IEA     neuron differentiation GO:0030182 IEA     regulatory ncRNA-mediated heterochromatin formation GO:0031048 IGI     methylation GO:0032259 IEA     response to estradiol GO:0032355 IEA     response to vitamin A GO:0033189 IEA     response to cocaine GO:0042220 IEA     negative regulation of gene expression via chromosomal CpG island methylation GO:0044027 IDA     negative regulation of DNA-templated transcription GO:0045892 IBA     cellular response to amino acid stimulus GO:0071230 IEA     cellular response to ethanol GO:0071361 IEA     cellular response to hypoxia GO:0071456 IEA     hepatocyte apoptotic process GO:0097284 IEA     autosome genomic imprinting GO:0141068 IEA     transposable element silencing by piRNA-mediated DNA methylation GO:0141196 IEA     positive regulation of cellular response to hypoxia GO:1900039 IEA     cellular response to bisphenol A GO:1903926 IEA Subcellular Localization     chromosome, centromeric region GO:0000775 IEA     euchromatin GO:0000791 IDA     heterochromatin GO:0000792 IEA     XY body GO:0001741 IEA     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 NAS     nucleoplasm GO:0005654 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     nuclear matrix GO:0016363 IDA     catalytic complex GO:1902494 IPI