Gene description for IFT80
Gene name intraflagellar transport 80
Gene symbol IFT80
Other names/aliases ATD2
SRTD2
WDR56
Species Homo sapiens
 Database cross references - IFT80
ExoCarta ExoCarta_57560
Vesiclepedia VP_57560
Entrez Gene 57560
HGNC 29262
MIM 611177
UniProt Q9P2H3  
 IFT80 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for IFT80
Biological Process
    osteoblast differentiation GO:0001649 IEA
    endochondral ossification GO:0001958 IEA
    growth plate cartilage chondrocyte differentiation GO:0003418 IEA
    apoptotic process GO:0006915 IEA
    establishment or maintenance of cell polarity GO:0007163 IEA
    smoothened signaling pathway GO:0007224 IEA
    canonical NF-kappaB signal transduction GO:0007249 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    gene expression GO:0010467 IEA
    proteasomal protein catabolic process GO:0010498 IEA
    negative regulation of keratinocyte proliferation GO:0010839 IEA
    protein ubiquitination GO:0016567 IEA
    spinal cord development GO:0021510 IEA
    osteoclast differentiation GO:0030316 IEA
    osteoblast proliferation GO:0033687 IEA
    multicellular organism growth GO:0035264 IEA
    non-canonical Wnt signaling pathway GO:0035567 IEA
    bone mineralization involved in bone maturation GO:0035630 IEA
    intraciliary anterograde transport GO:0035720 NAS
    phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IEA
    keratinocyte proliferation GO:0043616 IEA
    tooth eruption GO:0044691 IEA
    stem cell differentiation GO:0048863 IEA
    protein stabilization GO:0050821 IEA
    limb development GO:0060173 IEA
    cilium assembly GO:0060271 IBA
    cilium assembly GO:0060271 NAS
    articular cartilage development GO:0061975 IEA
    odontoblast differentiation GO:0071895 IEA
    stem cell proliferation GO:0072089 IEA
    receptor localization to non-motile cilium GO:0097500 IEA
    response to inositol GO:1902140 IEA
    non-motile cilium assembly GO:1905515 IEA
    cartilage homeostasis GO:1990079 IEA
    negative regulation of non-canonical Wnt signaling pathway GO:2000051 IEA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    centrosome GO:0005813 IBA
    cilium GO:0005929 IBA
    cilium GO:0005929 NAS
    cilium GO:0005929 TAS
    intraciliary transport particle B GO:0030992 IBA
    intraciliary transport particle B GO:0030992 IPI
    intraciliary transport particle B GO:0030992 ISS
    ciliary basal body GO:0036064 IEA
    ciliary tip GO:0097542 TAS
    9+0 non-motile cilium GO:0097731 IEA
 Experiment description of studies that identified IFT80 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IFT80
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IFT57 55081
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 TTC30A 92104
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 TTC26 79989
Affinity Capture-MS Homo sapiens
4 IFT20 90410
Affinity Capture-MS Homo sapiens
5 CLUAP1 23059
Affinity Capture-MS Homo sapiens
6 UBXN10  
Reconstituted Complex Homo sapiens
7 TRAF3IP1 26146
Affinity Capture-MS Homo sapiens
8 HSPB11 51668
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 IFT27 11020
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 IFT81 28981
Affinity Capture-MS Homo sapiens
11 TTC30B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 APEX1 328
Affinity Capture-RNA Homo sapiens
13 ABTB2 25841
Affinity Capture-MS Homo sapiens
14 IFT46 56912
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 ZUFSP 221302
Affinity Capture-MS Homo sapiens
16 IFT74 80173
Affinity Capture-MS Homo sapiens
17 FGF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 IFT52 51098
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
19 IFT88 8100
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
20 KXD1 79036
Affinity Capture-MS Homo sapiens
21 CORO1A 11151
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 PLXNA2 5362
Two-hybrid Homo sapiens
23 DNAJB1 3337
Proximity Label-MS Homo sapiens
24 NUDC 10726
Affinity Capture-MS Homo sapiens
25 IFT172 26160
Affinity Capture-MS Homo sapiens
26 IFT22 64792
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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